泛发性 eruptive 角化棘皮瘤（格日博夫斯基变型）。（注：“eruptive”常见释义为“发疹性的” ，这里结合医学语境可能有更准确专业的表述，但仅按要求翻译）

Generalized eruptive keratoacanthoma (Grzybowski variant).

作者信息

Consigli J E, González M E, Morsino R, Guidi A, Chappuis J M, Papa M, Maldonado S

机构信息

Department of Dermatology, Córdoba Hospital, Córdoba, Argentina.

出版信息

Br J Dermatol. 2000 Apr;142(4):800-3. doi: 10.1046/j.1365-2133.2000.03430.x.

DOI:10.1046/j.1365-2133.2000.03430.x

PMID:10792236

Abstract

We describe a patient with generalized eruptive keratoacanthoma (KA) of Grzybowski showing the characteristic features of this extremely rare condition. Since the first description by Grzybowski in 1950, only 28 additional cases (including the present one) have been reported. This variety of KA most commonly affects patients during the fifth to seventh decade of life and appears as a generalized eruption of hundreds to thousands of follicular papules. The small pruriginous papules often have a keratotic centre and show microscopic features of KA. Marked facial involvement is characteristic and can lead to masked facies with ectropion, as in our patient. The course of the disease is chronic and the response to therapy is poor.

摘要

我们描述了一名患有格日博夫斯基型泛发性 eruptive 角化棘皮瘤（KA）的患者，该患者展现出了这种极为罕见病症的特征。自1950年格日博夫斯基首次描述该病以来，仅另外报道了28例病例（包括本病例）。这种类型的KA最常发生于50至70岁的患者，表现为数百至数千个毛囊性丘疹的泛发性皮疹。微小的瘙痒性丘疹通常有角质化中心，并呈现出KA的微观特征。显著的面部受累是其特征，可导致睑外翻形成面具脸，就像我们的患者一样。该病病程慢性，对治疗反应不佳。