Jaber P W, Cooper P H, Greer K E
Department of Dermatology, University of Virginia School of Medicine.
J Am Acad Dermatol. 1993 Aug;29(2 Pt 2):299-304. doi: 10.1016/0190-9622(93)70180-2.
A patient with generalized eruptive keratoacanthoma of Grzybowski is described. Our findings, along with those of the 21 reported cases from the world literature, are summarized. This rare variant of keratoacanthoma most commonly affects patients in the fifth to seventh decades of life and appears as a generalized eruption of hundreds to thousands of follicular papules. These small papules often have a keratotic center and demonstrate the microscopic features of keratoacanthoma. Marked facial involvement is characteristic and can lead to masked facies with ectropion. Severe pruritus, mucosal lesions, and koebnerization are features of the disease. The course is chronic and the response to therapy is poor, although a few patients have improved with the use of systemic retinoids.
本文描述了一例Grzybowski泛发性爆发性角化棘皮瘤患者。我们的发现以及世界文献报道的21例病例的发现进行了总结。这种罕见的角化棘皮瘤变体最常影响50至70岁的患者，表现为数百至数千个毛囊丘疹的泛发性皮疹。这些小丘疹通常有角质化中心，并表现出角化棘皮瘤的微观特征。面部明显受累是其特征，可导致睑外翻的面具脸。严重瘙痒、黏膜病变和同形反应是该疾病的特征。病程是慢性的，对治疗的反应较差，尽管少数患者使用系统性维甲酸后有所改善。
