Vural E, Hutcheson J, Korourian S, Kechelava S, Hanna E
Department of Otolaryngology-Head and Neck Surgery, University of Arkansas for Medical Sciences, Little Rock 72205, USA.
Otolaryngol Head Neck Surg. 2000 May;122(5):717-20. doi: 10.1016/S0194-5998(00)70203-8.
Perineural spread (PNS) is a poor prognostic factor associated with increased risk of local recurrence and nodal metastasis and reduced survival of patients with squamous cell carcinoma of the head and neck (SCCHN). There is some evidence to indicate that neural cell adhesion molecules (NCAMs) may play a role in PNS of a variety of tumor types. We performed this study to investigate whether NCAM expression can be used as a predictor of PNS in SCCHN. The surgical specimens of 66 patients with SCCHN were evaluated with monoclonal IgG antibody immunoperoxidase staining for NCAM. Of the 41 specimens with PNS, 38 (93%) showed evidence of NCAM expression. In contrast, only 9 specimens (36%) without PNS expressed NCAMs. The difference in NCAM expression between the study and control groups was statistically significant (P < 0.01).
神经周围扩散（PNS）是一种预后不良的因素，与头颈部鳞状细胞癌（SCCHN）患者局部复发和淋巴结转移风险增加以及生存率降低相关。有证据表明神经细胞黏附分子（NCAMs）可能在多种肿瘤类型的PNS中发挥作用。我们进行这项研究以调查NCAM表达是否可作为SCCHN中PNS的预测指标。对66例SCCHN患者的手术标本用抗NCAM单克隆IgG抗体免疫过氧化物酶染色进行评估。在41例有PNS的标本中，38例（93%）显示有NCAM表达证据。相比之下，无PNS的标本中只有9例（36%）表达NCAMs。研究组和对照组之间NCAM表达的差异具有统计学意义（P<0.01）。
