D'Ambrosia R D, Lipscomb P R, McClain E J, Wissinger H A, McDowell J H
Surg Gynecol Obstet. 1975 Apr;140(4):523-7.
In the prevention of thromboembolic complications following elective total hip operations, warfarin is a safe and effective agent which causes minimal bleeding complications, if the drug is first administered on the first postoperative day and thereafter continued in various dosages to maintain a prothrombin time between one and one and one-half and two times that of the control. Dextran also is effective in preventing thromboembolic complications but causes more bleeding problems, especially when administered intraoperatively.
在预防择期全髋关节置换术后血栓栓塞并发症方面，华法林是一种安全有效的药物，若在术后第一天首次给药，然后继续以不同剂量维持凝血酶原时间在对照值的1至1.5倍和2倍之间，其引起的出血并发症最少。右旋糖酐在预防血栓栓塞并发症方面也有效，但会引发更多出血问题，尤其是在术中给药时。
