Jennings J J, Harris W H, Sarmiento A
J Bone Joint Surg Am. 1976 Oct;58(7):926-8.
Prophylaxis of thromboembolic disease using aspirin was studied prospectively in 340 patients undergoing total hip replacement, excluding those with prior thromboembolic disease. Clinical criteria were used to diagnose thrombophlebitis, while clinical criteria, roentgenography, blood-gas determinations, electrocardiography, and pulmonary vascular scanning were used to diagnose pulmonary emboli. Five patients had signs of symptoms of pulmonary emboli, all confirmed by pulmonary vascular scan. No fatal pulmonary emboli occurred. Twenty-six patients had thrombophlebitis. Without simultaneous control group, a reduction in postoperative thromboembolic disease in these patients receiving aspirin was not proved. However, the observed low incidence of clinically evident thromboembolic manifestations suggests that aspirin may be a simple and useful prophylactic agent in these patients.
对340例接受全髋关节置换术且无既往血栓栓塞性疾病的患者进行了前瞻性研究，以探讨使用阿司匹林预防血栓栓塞性疾病的效果。采用临床标准诊断血栓性静脉炎，同时采用临床标准、X线摄影、血气测定、心电图及肺血管扫描诊断肺栓塞。5例患者出现肺栓塞症状体征，均经肺血管扫描证实。未发生致命性肺栓塞。26例患者发生血栓性静脉炎。由于没有同期对照组，因此未能证实接受阿司匹林治疗的这些患者术后血栓栓塞性疾病有所减少。然而，观察到的临床明显血栓栓塞表现的低发生率表明，阿司匹林可能是这些患者一种简单而有用的预防药物。
