Carman G M, Henry S A
Department of Food Science, Cook College, New Jersey Agricultural Experiment Station, Rutgers University, New Brunswick 08901, USA.
Prog Lipid Res. 1999 Sep-Nov;38(5-6):361-99. doi: 10.1016/s0163-7827(99)00010-7.
In this review, we have discussed recent progress in the study of the regulation that controls phospholipid metabolism in S. cerevisiae. This regulation occurs on multiple levels and is tightly integrated with a large number of other cellular processes and related metabolic and signal transduction pathways. Progress in deciphering this complex regulation has been very rapid in the last few years, aided by the availability of the sequence of the entire Saccharomyces genome. The assignment of functions to the remaining unassigned open reading frames, as well as ascertainment of remaining gene-enzyme relationships in phospholipid biosynthesis in yeast, promises to provide detailed understanding of the genetic regulation of a crucial area of metabolism in a key eukaryotic model system. Since the processes of lipid metabolism, secretion, and signal transduction show fundamental similarities in all eukaryotes, the dissection of this regulation in yeast promises to have wide application to our understanding of metabolic control in all eukaryotes.
在本综述中，我们讨论了酿酒酵母中控制磷脂代谢的调控机制研究的最新进展。这种调控发生在多个层面，并与大量其他细胞过程以及相关的代谢和信号转导途径紧密整合。在过去几年中，借助酿酒酵母全基因组序列的可得性，在解读这一复杂调控方面取得了非常迅速的进展。对其余未分配功能的开放阅读框进行功能分配，以及确定酵母中磷脂生物合成中剩余的基因-酶关系，有望为深入理解关键真核模型系统中一个关键代谢领域的遗传调控提供详细信息。由于脂质代谢、分泌和信号转导过程在所有真核生物中表现出基本的相似性，因此在酵母中剖析这种调控有望广泛应用于我们对所有真核生物代谢控制的理解。
