Qian W, Graciano A, Haight J S, McClean P, Zamel N, Chapnik J S
Zhenjiang First People's Hospital, Jiangsu, China.
Am J Rhinol. 2000 Mar-Apr;14(2):121-4. doi: 10.2500/105065800781692930.
This prospective study was undertaken to determine whether topical nasal anesthetic agents affect nasal nitric oxide (NO) output in healthy adults. Seven volunteers (aged: 29-56 (40.6 +/- 10.7) years, six male), were recruited. A topical anesthetic (4% lidocaine or 0.5% tetracaine) was sprayed into the subject's right nostril while the left nostril served as a control. Unilateral nasal NO and nasal volume were measured before administration of the anesthetic and at 15 and 30 minutes after the administration. The mean (+/- SD) unilateral nasal NO output was 307 +/- 45.9 nL/minute from the right nostril (exposure side) before the topical application of lidocaine. At 30 minutes after topical application (n = 6), it was 295.5 +/- 41.5 in the right nostril and 297.5 +/- 39.8 in the left (control side). In the tetracaine group (n = 7), the mean (+/- SD) unilateral nasal NO output was 302 +/- 53.3 before the administration and 307 +/- 39.7 at 30 minutes after the administration in the right nostril. The mean NO output in the left nostril at 30 minutes after the administration was 297.7 +/- 40.75. In neither group was there any significant difference in nasal NO output between either the pre- and postlocal anesthetic application on the exposure side (Group 1, P = 0.76; group 2, P = 0.41) or the two nostrils after topical anesthesia application (group 1, P = 0.83; group 2, P = 0.62). Topical anesthesia with either lidocaine or tetracaine does not alter nasal NO output. NO measurement should not be affected in circumstances that require topical anesthesia of the nasal cavity.
本前瞻性研究旨在确定局部鼻腔麻醉剂是否会影响健康成年人的鼻腔一氧化氮（NO）排出量。招募了7名志愿者（年龄：29 - 56（40.6±10.7）岁，6名男性）。将局部麻醉剂（4%利多卡因或0.5%丁卡因）喷入受试者右侧鼻孔，左侧鼻孔作为对照。在给予麻醉剂前以及给药后15分钟和30分钟测量单侧鼻腔NO和鼻腔容积。在局部应用利多卡因前，右侧鼻孔（暴露侧）的平均（±标准差）单侧鼻腔NO排出量为307±45.9 nL/分钟。局部应用后30分钟（n = 6），右侧鼻孔为295.5±41.5，左侧（对照侧）为297.5±39.8。在丁卡因组（n = 7）中，给药前右侧鼻孔的平均（±标准差）单侧鼻腔NO排出量为302±53.3，给药后30分钟为307±39.7。给药后30分钟左侧鼻孔的平均NO排出量为297.7±40.75。两组中，暴露侧局部麻醉前后（第1组，P = 0.76；第2组，P = 0.41）或局部麻醉应用后两个鼻孔之间（第1组，P = 0.83；第2组，P = 0.62）的鼻腔NO排出量均无显著差异。利多卡因或丁卡因局部麻醉不会改变鼻腔NO排出量。在需要鼻腔局部麻醉的情况下，NO测量不应受到影响。
