Culviner W T, Leonard D W, Wilhelmsen C L, Bolger W E
Department of Otolaryngology, National Naval Medical Center, Bethesda, Maryland, USA.
Am J Rhinol. 2000 Mar-Apr;14(2):131-7. doi: 10.2500/105065800781692877.
Myospherulosis or lipogranuloma formation is frequently iatrogenic and is caused by a petrolatum, lanolin, or paraffin-based ointment becoming trapped within tissue. Four different ointments, including the newly available Bactroban nasal, were studied in a rabbit paranasal sinus model to evaluate their proclivity to induce myospherulosis. The maxillary sinuses of 16 New Zealand white rabbits were bilaterally inoculated with Bactroban, Bactroban nasal, tetracycline, or bacitracin ointments and compared to saline controls in two rabbits. Sinus specimens were harvested at 2 and 4-week intervals and processed for histologic study. Myospherulosis formation was uniformly induced with the Bactroban nasal, bacitracin, and tetracycline ointments in 8/8, 7/8, and 8/8 sinuses, respectively. In contrast, myospherulosis was not induced in the 5/8 of the sinuses using Bactroban. The data from this investigation indicate that Bactroban nasal (paraffin vehicle) is similar to bacitracin and tetracycline ointments (petrolatum and petrolatum-lanolin vehicles) in that they all can cause myospherulosis. In contrast, Bactroban (a water-soluble, polyethylene glycol base) causes myospherulosis to a much smaller extent. Our results emphasize the differences between the two types of Bactroban preparations and provide objective data that can be evaluated by otolaryngologists who apply these ointments following nasal cavity surgery.
肌球孢子菌病或脂性肉芽肿形成常为医源性，由凡士林、羊毛脂或石蜡基软膏滞留在组织内所致。在兔鼻旁窦模型中研究了四种不同的软膏，包括新上市的鼻用百多邦，以评估它们诱发肌球孢子菌病的倾向。给16只新西兰白兔的双侧上颌窦接种百多邦、鼻用百多邦、四环素或杆菌肽软膏，并与两只接种生理盐水的对照兔进行比较。每隔2周和4周采集鼻窦标本并进行组织学研究。鼻用百多邦、杆菌肽和四环素软膏分别在8/8、7/8和8/8个鼻窦中均一致诱发了肌球孢子菌病形成。相比之下，使用百多邦的8个鼻窦中有5个未诱发肌球孢子菌病。该研究的数据表明，鼻用百多邦（石蜡基质）与杆菌肽和四环素软膏（凡士林和凡士林-羊毛脂基质）相似，因为它们都可引起肌球孢子菌病。相比之下，百多邦（水溶性聚乙二醇基质）引起肌球孢子菌病的程度要小得多。我们的结果强调了两种百多邦制剂之间的差异，并提供了客观数据，可供鼻腔手术后使用这些软膏的耳鼻喉科医生评估。
