Wheeler T M, Sessions R B, McGavran M H
Arch Otolaryngol. 1980 May;106(5):272-4. doi: 10.1001/archotol.1980.00790290024009.
We discuss a disorder that, although at first considered of possible fungal origin, now is known to be due to an alteration of erythrocytes induced by petrolatum-based antibiotic ointment. In this country, the structures of myospherulosis have been seen most often in tissues from the nose and paranasal sinuses following surgery in this region. Our studies show that both components of the vehicle of a commonly used tetracycline antibiotic ointment, lanolin and petrolatum, either separately or together, produce the structures of myospherulosis in vitro. It is recommended that a nonpetrolatum-based substance be used in nasal packing for purposes of hemostasis.
我们讨论一种疾病，尽管最初认为可能源于真菌，但现在已知是由凡士林基抗生素软膏引起的红细胞改变所致。在这个国家，在该区域手术后，鼻球孢子菌病的结构最常出现在鼻子和鼻窦的组织中。我们的研究表明，常用四环素抗生素软膏的赋形剂的两种成分，羊毛脂和凡士林，单独或一起使用，均可在体外产生鼻球孢子菌病的结构。建议在鼻腔填塞止血时使用非凡士林基物质。
