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曲伐沙星对557株厌氧菌的体外活性

In vitro activities of trovafloxacin against 557 strains of anaerobic bacteria.

作者信息

Wexler H M, Molitoris E, Molitoris D, Finegold S M

机构信息

Medical Services, Veterans Administration Medical Center, West Los Angeles, California 90073, USA.

出版信息

Antimicrob Agents Chemother. 1996 Sep;40(9):2232-5. doi: 10.1128/AAC.40.9.2232.

DOI:10.1128/AAC.40.9.2232
PMID:8878617
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC163509/
Abstract

The antimicrobial activity of trovafloxacin for 557 strains of anaerobic bacteria was determined by the National Committee for Clinical Laboratory Standards-approved Wadsworth agar dilution technique. The species tested included Bacteroides fragilis (n = 91), other members of the B. fragilis group (n = 130), Campylobacter gracilis (n = 15), other Bacteroides spp. (n = 16), Prevotella spp. (n = 49), Porphyromonas spp. (n = 15), Fusobacterium spp. (n = 62), Bilophila wadsworthia (n = 24), Sutterella wadsworthensis (n = 21), Clostridium spp. (n = 61), Peptostreptococcus spp. (n = 38), and gram-positive non-spore-forming rods (n = 35). Trovafloxacin inhibited all strains of B. fragilis at < or = 0.5 microgram/ml, 99% of other B. fragilis group species at < or = 2 micrograms/ml, and 96% of all anaerobes tested at < or = 2 micrograms/ml.

摘要

采用美国国家临床实验室标准委员会认可的沃兹沃思琼脂稀释技术，测定了曲伐沙星对557株厌氧菌的抗菌活性。所检测的菌种包括脆弱拟杆菌（n = 91）、脆弱拟杆菌群的其他成员（n = 130）、纤细弯曲菌（n = 15）、其他拟杆菌属菌种（n = 16）、普雷沃菌属菌种（n = 49）、卟啉单胞菌属菌种（n = 15）、梭杆菌属菌种（n = 62）、沃兹沃思嗜胆菌（n = 24）、沃兹沃思萨特菌（n = 21）、梭菌属菌种（n = 61）、消化链球菌属菌种（n = 38）以及革兰氏阳性无芽孢杆菌（n = 35）。曲伐沙星对所有脆弱拟杆菌菌株的最低抑菌浓度≤0.5微克/毫升，对99%的其他脆弱拟杆菌群菌种的最低抑菌浓度≤2微克/毫升，对96%的所有受试厌氧菌的最低抑菌浓度≤2微克/毫升。

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