Wexler H M, Molitoris E, Finegold S M
Research Service, Veterans Administration Medical Center, West Los Angeles, California 90073.
Antimicrob Agents Chemother. 1993 Nov;37(11):2509-13. doi: 10.1128/AAC.37.11.2509.
The antimicrobial activity of a new quinolone, Bay Y3118, was determined against 326 strains of anaerobic bacteria and compared with the activities of ampicillin-sulbactam, cefotetan, clindamycin, imipenem, metronidazole, and sparfloxacin. The National Committee for Clinical Laboratory Standards-approved Wadsworth agar dilution technique with Brucella-laked blood agar was used throughout the study. Breakpoints used to determine the percent susceptible were 2 micrograms/ml for Bay Y3118 and sparfloxacin, 4 micrograms/ml for clindamycin, 8 micrograms/ml for imipenem, 16 micrograms/ml for metronidazole and ampicillin-sulbactam, and 32 micrograms/ml for cefotetan. Species tested included Bacteroides fragilis (57 strains), other B. fragilis group species (79 strains), Bacteroides gracilis (10 strains), other Bacteroides spp. (9 strains), Prevotella spp. (30 strains), Porphyromonas spp. (9 strains), Fusobacterium spp. (36 strains), Bilophila wadsworthia (14 strains), Clostridium spp. (36 strains), Peptostreptococcus spp. (20 strains), and gram-positive non-spore-forming rods (26 strains). Bay Y3118 inhibited all but 1 of 326 anaerobic bacteria tested at the breakpoint level or lower.
测定了一种新型喹诺酮类药物Bay Y3118对326株厌氧菌的抗菌活性，并与氨苄西林-舒巴坦、头孢替坦、克林霉素、亚胺培南、甲硝唑和司帕沙星的活性进行了比较。在整个研究过程中，采用了美国国家临床实验室标准委员会批准的、以布鲁氏菌溶解血琼脂为培养基的沃兹沃思琼脂稀释技术。用于确定敏感百分比的断点浓度分别为：Bay Y3118和司帕沙星为2微克/毫升，克林霉素为4微克/毫升，亚胺培南为8微克/毫升，甲硝唑和氨苄西林-舒巴坦为16微克/毫升，头孢替坦为32微克/毫升。检测的菌种包括脆弱拟杆菌（57株）、其他脆弱拟杆菌属菌种（79株）、纤细拟杆菌（10株）、其他拟杆菌属菌种（9株）、普雷沃菌属菌种（30株）、卟啉单胞菌属菌种（9株）、梭杆菌属菌种（36株）、沃兹沃思嗜胆菌（14株）、梭菌属菌种（36株）、消化链球菌属菌种（20株）和革兰氏阳性无芽孢杆菌（26株）。在断点浓度或更低浓度下，Bay Y3118抑制了所检测的326株厌氧菌中的325株。
