北爱尔兰的α1抗胰蛋白酶表型
Alpha1 antitrypsin phenotypes in Northern Ireland.
作者信息
Blundell G, Frazer A
出版信息
Ann Hum Genet. 1975 Jan;38(3):289-94. doi: 10.1111/j.1469-1809.1975.tb00612.x.
Serum alpha1 antitrypsin levels and phenotypes were examined in 1000 healthy adults in Northern Ireland. The Pi phenotype M accounted for 87-8% Pi MS for 7-3% and Pi MZ for 3-5%. The percentages of the rarer phenotypes were Pi FM 0-3, Pi IM 0-6, Pi SZ 0-4 and Pi Z--0-1. The range of alpha1 antitrypsin levels in different phenotypes showed considerable overlap. Pi MS, Pi MZ and Pi SZ sera gave mean levels of 81%, 61% and 40% respectively of the mean level obtained in Pi M sera and that of the Pi Z--minus serum, 5%. Two distinct types of anomalous pattern were encountered in sera from ten subjects.
在北爱尔兰的1000名健康成年人中检测了血清α1抗胰蛋白酶水平和表型。Pi表型M占87.8%，Pi MS占7.3%，Pi MZ占3.5%。较罕见表型的百分比分别为Pi FM 0.3%、Pi IM 0.6%、Pi SZ 0.4%和Pi Z--0.1%。不同表型的α1抗胰蛋白酶水平范围有相当大的重叠。Pi MS、Pi MZ和Pi SZ血清的平均水平分别为Pi M血清平均水平的81%、61%和40%，而Pi Z--血清的平均水平为5%。在10名受试者的血清中发现了两种不同类型的异常模式。
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