呼吸道合胞病毒：1990 - 1996年阿根廷儿童中A、B亚组流行率的变化

Respiratory syncytial virus: changes in prevalence of subgroups A and B among Argentinian children, 1990-1996.

作者信息

Carballal G, Videla C, Sequeira M D, Mistchenko A, Requeijo P V, Arbiza J

机构信息

Laboratorio de Virología, Centro de Educación Médica e Investigaciones Clínicas N. Quirno (CEMIC), Buenos Aires, Argentina.

出版信息

J Med Virol. 2000 Jun;61(2):275-9. doi: 10.1002/(sici)1096-9071(200006)61:2<275::aid-jmv15>3.0.co;2-e.

DOI:10.1002/(sici)1096-9071(200006)61:2<275::aid-jmv15>3.0.co;2-e

PMID:10797385

Abstract

The frequency of respiratory syncytial virus (RSV) and the distribution of subgroups A and B strains during 7 consecutive years (1990-1996) were examined in two cities of Argentina. Nasopharyngeal aspirates from 1,304 children less than 2 years of age hospitalized with acute lower respiratory infection were studied by indirect immunofluorescence. RSV was detected in 352 cases (26.9%), and the peak activity was observed in midwinter. Subgroup characterization was performed with two monoclonal antibodies against the F protein on nasopharyngeal aspirate smears. Of 195 samples, 174 (89.2%) were identified as subgroup A strains and 21 (10.8%) as subgroup B. Both strains cocirculated during 5 of 7 years studied with subgroup A predominating. Subgroup A occurred at least 8 times as often in all years except for 1994-1995. Children infected by subgroup A were younger than those infected by subgroup B (P < 0.05). The association of subgroup A infection with bronchiolitis and subgroup B with pneumonia was statistically significant (P < 0.03).

摘要

在阿根廷的两个城市，对连续7年（1990 - 1996年）期间呼吸道合胞病毒（RSV）的感染频率以及A、B亚组毒株的分布情况进行了调查。通过间接免疫荧光法对1304名因急性下呼吸道感染住院的2岁以下儿童的鼻咽抽吸物进行了研究。在352例（26.9%）病例中检测到RSV，其活动高峰出现在冬季中期。使用两种针对F蛋白的单克隆抗体对鼻咽抽吸物涂片进行亚组鉴定。在195份样本中，174份（89.2%）被鉴定为A亚组毒株，21份（10.8%）为B亚组。在研究的7年中有5年两种毒株同时流行，且以A亚组为主。除1994 - 1995年外，A亚组在所有年份出现的频率至少是B亚组的8倍。感染A亚组的儿童比感染B亚组的儿童年龄更小（P < 0.05）。A亚组感染与细支气管炎、B亚组感染与肺炎之间的关联具有统计学意义（P < 0.03）。