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1
Secretory leukocyte protease inhibitor inhibits infection of monocytes and lymphocytes with human immunodeficiency virus type 1 but does not interfere with transcytosis of cell-associated virus across tight epithelial barriers.分泌型白细胞蛋白酶抑制剂可抑制1型人类免疫缺陷病毒对单核细胞和淋巴细胞的感染，但不干扰细胞相关病毒穿过紧密上皮屏障的转胞吞作用。
Clin Diagn Lab Immunol. 2000 May;7(3):515-8. doi: 10.1128/CDLI.7.3.515-518.2000.
2
Human immunodeficiency virus type-1 (HIV-1) replication is unaffected by human secretory leukocyte protease inhibitor.1型人类免疫缺陷病毒（HIV-1）的复制不受人类分泌型白细胞蛋白酶抑制剂的影响。
Antiviral Res. 1996 Mar;29(2-3):269-77. doi: 10.1016/0166-3542(95)00907-8.
3
Inhibitory function of secretory leukocyte proteinase inhibitor (SLPI) in human saliva is HIV-1 specific and varies with virus tropism.人唾液中分泌型白细胞蛋白酶抑制剂（SLPI）的抑制功能具有HIV-1特异性，并随病毒嗜性而变化。
Oral Dis. 2002 May;8(3):160-7. doi: 10.1034/j.1601-0825.2002.01807.x.
4
Secretory leukocyte protease inhibitor: a human saliva protein exhibiting anti-human immunodeficiency virus 1 activity in vitro.分泌型白细胞蛋白酶抑制剂：一种在体外具有抗人免疫缺陷病毒1活性的人唾液蛋白。
J Clin Invest. 1995 Jul;96(1):456-64. doi: 10.1172/JCI118056.
5
Secretory leukocyte protease inhibitor blocks infectivity of primary monocytes and mononuclear cells with both monocytotropic and lymphocytotropic strains of human immunodeficiency virus type I.分泌型白细胞蛋白酶抑制剂可阻断人免疫缺陷病毒I型嗜单核细胞和嗜淋巴细胞毒株对原代单核细胞和单核细胞的感染性。
Oral Dis. 1997 May;3 Suppl 1:S70-2. doi: 10.1111/j.1601-0825.1997.tb00379.x.
6
Secretory leukocyte protease inhibitor: inhibition of human immunodeficiency virus-1 infection of monocytic THP-1 cells by a newly cloned protein.分泌型白细胞蛋白酶抑制剂：一种新克隆的蛋白质对人免疫缺陷病毒1型感染单核细胞THP-1细胞的抑制作用
Bioorg Chem. 2002 Aug;30(4):249-63. doi: 10.1016/s0045-2068(02)00008-1.
7
Inhibition of human immunodeficiency virus type 1 infectivity by secretory leukocyte protease inhibitor occurs prior to viral reverse transcription.分泌型白细胞蛋白酶抑制剂对1型人类免疫缺陷病毒感染性的抑制作用发生在病毒逆转录之前。
Blood. 1997 Aug 1;90(3):1141-9.
8
Uterine-associated serine protease inhibitors stimulate deoxyribonucleic acid synthesis in porcine endometrial glandular epithelial cells of pregnancy.子宫相关丝氨酸蛋白酶抑制剂刺激妊娠母猪子宫内膜腺上皮细胞中的脱氧核糖核酸合成。
Biol Reprod. 1999 Aug;61(2):380-7. doi: 10.1095/biolreprod61.2.380.
9
Secretory leukocyte protease inhibitor (SLPI) in mucosal fluids inhibits HIV-I.粘膜液中的分泌型白细胞蛋白酶抑制剂（SLPI）可抑制HIV-1。
Oral Dis. 1997 May;3 Suppl 1:S64-9. doi: 10.1111/j.1601-0825.1997.tb00377.x.
10
Secretory leukocyte protease inhibitor suppresses the production of monocyte prostaglandin H synthase-2, prostaglandin E2, and matrix metalloproteinases.分泌型白细胞蛋白酶抑制剂可抑制单核细胞前列腺素H合成酶-2、前列腺素E2和基质金属蛋白酶的产生。
J Clin Invest. 1997 Mar 1;99(5):894-900. doi: 10.1172/JCI119254.

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1
Breast Milk and Saliva Lactoferrin Levels and Postnatal Cytomegalovirus Infection.母乳和唾液乳铁蛋白水平与产后巨细胞病毒感染。
Am J Perinatol. 2021 Aug;38(10):1070-1077. doi: 10.1055/s-0040-1701609. Epub 2020 Feb 18.
2
A Longitudinal Assessment of Cervical Inflammation and Immunity Associated with HIV-1 Infection, Hormonal Contraception, and Pregnancy.一项关于与HIV-1感染、激素避孕及妊娠相关的宫颈炎症和免疫的纵向评估。
AIDS Res Hum Retroviruses. 2018 Oct;34(10):889-899. doi: 10.1089/AID.2018.0022. Epub 2018 Sep 5.
3
Non-Cationic Proteins Are Associated with HIV Neutralizing Activity in Genital Secretions of Female Sex Workers.非阳离子蛋白与女性性工作者生殖道分泌物中的HIV中和活性相关。
PLoS One. 2015 Jun 19;10(6):e0130404. doi: 10.1371/journal.pone.0130404. eCollection 2015.
4
Regulation of mucosal immunity in the female reproductive tract: the role of sex hormones in immune protection against sexually transmitted pathogens.女性生殖道黏膜免疫的调节：性激素在针对性传播病原体的免疫保护中的作用。
Am J Reprod Immunol. 2014 Aug;72(2):236-58. doi: 10.1111/aji.12252. Epub 2014 Apr 16.
5
Tenascin-C is an innate broad-spectrum, HIV-1-neutralizing protein in breast milk.Tenascin-C 是母乳中一种先天广谱、HIV-1 中和的蛋白质。
Proc Natl Acad Sci U S A. 2013 Nov 5;110(45):18220-5. doi: 10.1073/pnas.1307336110. Epub 2013 Oct 21.
6
The oral mucosa immune environment and oral transmission of HIV/SIV.口腔黏膜免疫环境与 HIV/SIV 的口腔传播。
Immunol Rev. 2013 Jul;254(1):34-53. doi: 10.1111/imr.12078.
7
Short communication: HIV type 1 subtype C variants transmitted through the bottleneck of breastfeeding are sensitive to new generation broadly neutralizing antibodies directed against quaternary and CD4-binding site epitopes.简短通讯：通过母乳喂养瓶颈传播的1型人类免疫缺陷病毒C亚型变体对新一代针对四级和CD4结合位点表位的广泛中和抗体敏感。
AIDS Res Hum Retroviruses. 2013 Mar;29(3):511-5. doi: 10.1089/AID.2012.0197. Epub 2013 Jan 18.
8
Anti-HIV-1 activity of elafin is more potent than its precursor's, trappin-2, in genital epithelial cells.Elafin 对 HIV-1 的抗病毒活性比其前体 trappin-2 更强，在生殖道上皮细胞中。
J Virol. 2012 Apr;86(8):4599-610. doi: 10.1128/JVI.06561-11. Epub 2012 Feb 15.
9
Innate and adaptive immunity at mucosal surfaces of the female reproductive tract: stratification and integration of immune protection against the transmission of sexually transmitted infections.女性生殖道黏膜固有和适应性免疫：分层和整合免疫保护以防止性传播感染的传播。
J Reprod Immunol. 2011 Mar;88(2):185-94. doi: 10.1016/j.jri.2011.01.005. Epub 2011 Feb 26.
10
Epithelial cell secretions from the human female reproductive tract inhibit sexually transmitted pathogens and Candida albicans but not Lactobacillus.人体生殖道的上皮细胞分泌物可抑制性传播病原体和白色念珠菌，但不能抑制乳杆菌。
Mucosal Immunol. 2011 May;4(3):335-42. doi: 10.1038/mi.2010.72. Epub 2010 Nov 3.

本文引用的文献

1
Intracellular neutralization of HIV transcytosis across tight epithelial barriers by anti-HIV envelope protein dIgA or IgM.抗HIV包膜蛋白dIgA或IgM对HIV跨紧密上皮屏障转胞吞作用的细胞内中和作用。
Immunity. 1998 Aug;9(2):277-87. doi: 10.1016/s1074-7613(00)80610-x.
2
Epithelial uptake and transport of cell-free human immunodeficiency virus type 1 and gp120-coated microparticles.无细胞的1型人类免疫缺陷病毒和包被gp120的微粒的上皮摄取与转运
J Virol. 1998 May;72(5):4231-6. doi: 10.1128/JVI.72.5.4231-4236.1998.
3
Secretory leukocyte protease inhibitor blocks infectivity of primary monocytes and mononuclear cells with both monocytotropic and lymphocytotropic strains of human immunodeficiency virus type I.分泌型白细胞蛋白酶抑制剂可阻断人免疫缺陷病毒I型嗜单核细胞和嗜淋巴细胞毒株对原代单核细胞和单核细胞的感染性。
Oral Dis. 1997 May;3 Suppl 1:S70-2. doi: 10.1111/j.1601-0825.1997.tb00379.x.
4
Secretory leukocyte protease inhibitor (SLPI) in mucosal fluids inhibits HIV-I.粘膜液中的分泌型白细胞蛋白酶抑制剂（SLPI）可抑制HIV-1。
Oral Dis. 1997 May;3 Suppl 1:S64-9. doi: 10.1111/j.1601-0825.1997.tb00377.x.
5
The elastase-induced expression of secretory leukocyte protease inhibitor is decreased in remodelled airway epithelium.在重塑的气道上皮中，弹性蛋白酶诱导的分泌性白细胞蛋白酶抑制剂的表达降低。
Eur J Pharmacol. 1997 Oct 8;336(2-3):187-96. doi: 10.1016/s0014-2999(97)01222-3.
6
High-level ability of secretory IgA to block HIV type 1 transcytosis: contrasting secretory IgA and IgG responses to glycoprotein 160.
AIDS Res Hum Retroviruses. 1997 Sep 20;13(14):1179-85. doi: 10.1089/aid.1997.13.1179.
7
Inhibition of human immunodeficiency virus type 1 infectivity by secretory leukocyte protease inhibitor occurs prior to viral reverse transcription.分泌型白细胞蛋白酶抑制剂对1型人类免疫缺陷病毒感染性的抑制作用发生在病毒逆转录之前。
Blood. 1997 Aug 1;90(3):1141-9.
8
HIV coreceptor downregulation as antiviral principle: SDF-1alpha-dependent internalization of the chemokine receptor CXCR4 contributes to inhibition of HIV replication.作为抗病毒原理的HIV共受体下调：趋化因子受体CXCR4的SDF-1α依赖性内化有助于抑制HIV复制。
J Exp Med. 1997 Jul 7;186(1):139-46. doi: 10.1084/jem.186.1.139.
9
Anatomic dissociation between HIV-1 and its endogenous inhibitor in mucosal tissues.黏膜组织中HIV-1与其内源性抑制剂之间的解剖学分离。
Am J Pathol. 1997 Apr;150(4):1275-84.
10
Sexual transmission of HIV.艾滋病毒的性传播。
N Engl J Med. 1997 Apr 10;336(15):1072-8. doi: 10.1056/NEJM199704103361507.

分泌型白细胞蛋白酶抑制剂可抑制1型人类免疫缺陷病毒对单核细胞和淋巴细胞的感染，但不干扰细胞相关病毒穿过紧密上皮屏障的转胞吞作用。

Secretory leukocyte protease inhibitor inhibits infection of monocytes and lymphocytes with human immunodeficiency virus type 1 but does not interfere with transcytosis of cell-associated virus across tight epithelial barriers.

作者信息

Hocini H, Becquart P, Bouhlal H, Adle-Biassette H, Kazatchkine M D, Bélec L

机构信息

Unité INSERM U430, Paris, France.

出版信息

Clin Diagn Lab Immunol. 2000 May;7(3):515-8. doi: 10.1128/CDLI.7.3.515-518.2000.

DOI:10.1128/CDLI.7.3.515-518.2000
PMID:10799472
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC95905/
Abstract

In the present study, we demonstrate that recombinant human secretory leukocyte protease inhibitor (rhSLPI) inhibits infection of lymphocyte- and monocyte-derived tumor cell lines and peripheral blood lymphocytes with laboratory-adapted isolates and with the primary isolate, NDK, of free human immunodeficiency virus type 1 (HIV-1). In contrast, rhSLPI did not exhibit inhibitory activity toward transcytosis of cell-associated HIV-1 through a tight monolayer of endometrial epithelial cells. These observations indicate that the inhibitory effect of SLPI is restricted to free HIV-1 in corporal fluids.

摘要

在本研究中，我们证明重组人分泌型白细胞蛋白酶抑制剂（rhSLPI）可抑制实验室适应性分离株以及游离的1型人类免疫缺陷病毒（HIV-1）的原始分离株NDK对淋巴细胞和单核细胞衍生的肿瘤细胞系及外周血淋巴细胞的感染。相比之下，rhSLPI对细胞相关的HIV-1通过紧密的子宫内膜上皮细胞单层进行的转胞吞作用未表现出抑制活性。这些观察结果表明，SLPI的抑制作用仅限于体液中的游离HIV-1。