DeDecker B S
Harvard Institute of Chemistry and Cell Biology, Boston, MA 02115-5731, USA.
Chem Biol. 2000 May;7(5):R103-7. doi: 10.1016/s1074-5521(00)00115-0.
Recently, a class of small molecules that thermally stabilize the tumor suppressor p53 was selected from a small-molecule library. This, and other recent work, demonstrates the feasibility of taking a lead from nature and selecting new classes of drugs that function by allosteric mechanisms.
最近，从一个小分子文库中筛选出了一类能够热稳定肿瘤抑制因子p53的小分子。这项研究以及其他近期的工作证明了借鉴自然并筛选通过变构机制发挥作用的新型药物的可行性。
