Kanceljak-Macan B, Macan J, Buneta L, Milkovic-Kraus S
Institute for Medical Research and Occupational Health, Ksaverska cesta 2, 10000 Zagreb, Croatia,
Croat Med J. 2000 Mar;41(1):54-7.
Determination of prevalence of sensitization to Dermatophagoides pteronyssinus, Dermatophagoides farinae (pyroglyphid mites), Lepidoglyphus destructor, and Tyrophagus putrescentiae (non-pyroglyphid mites) in urban continental Croatia.
Specific IgE (sIgE) and skin prick test (SPT) for D. pteronyssinus, D. farinae, L. destructor, and T. putrescentiae were performed in 67 men. SPT was performed with Epipharm-ALK allergens. A urtica (D+d)/2 of 3 mm or greater was considered a positive skin reaction. SIgE was measured by immunoCAP technology (UNI CAP). Values <0.35 kUA/L were considered nonspecific and >0.35 kUA/L increased.
The prevalence of subjects with positive SPT was 35.8% for T. putrescentiae, 26.8% for L. destructor (26.8%), and 22. 4% for D. pteronyssinus and D. farinae. The prevalence of increased sIgE for D. pteronyssinus and D. farinae was 23.9%, followed by T. putrescentiae (22.4%), and L. destructor (14.9%). Among subjects with increased IgE to D. pteronyssinus there were also increased IgE for D. farinae in 94%, for T. putrescentiae in 75%, and for L. destructor in 50%. Mean urtica diameter differed only for L. destructor between nonspecific and increased sIgE values in subjects with positive SPT (3.7+/-0.7 mm vs. 6.2+/-2.8 mm; p = 0.004). Sensitization to storage mites was accompanied by respiratory symptoms in similar proportions as that to house dust mites (51.8% and 54.5%, respectively; p = 0.8527).
Sensitization to non-pyroglyphid mites is present in the general urban population of Croatia in similar proportions as to pyroglyphid mites, with the same range of respiratory symptoms. Testing with storage mites should be considered routine allergological diagnostic procedure.
确定克罗地亚大陆城市地区对屋尘螨、粉尘螨（嗜皮螨科螨类）、腐食酪螨和粗脚粉螨（非嗜皮螨科螨类）致敏的患病率。
对67名男性进行了针对屋尘螨、粉尘螨、腐食酪螨和粗脚粉螨的特异性IgE（sIgE）和皮肤点刺试验（SPT）。使用Epipharm-ALK过敏原进行SPT。风团（D+d）/2为3毫米或更大被视为阳性皮肤反应。通过免疫化学发光法（UNI CAP）测量sIgE。值<0.35 kUA/L被视为非特异性，>0.35 kUA/L为升高。
粗脚粉螨SPT阳性受试者的患病率为35.8%，腐食酪螨为26.8%，屋尘螨和粉尘螨为22.4%。屋尘螨和粉尘螨sIgE升高的患病率为23.9%，其次是粗脚粉螨（22.4%）和腐食酪螨（14.9%）。在对屋尘螨IgE升高的受试者中，对粉尘螨IgE升高的占94%，对粗脚粉螨IgE升高的占75%，对腐食酪螨IgE升高的占50%。在SPT阳性的受试者中，仅腐食酪螨的平均风团直径在非特异性和sIgE升高值之间存在差异（3.7±0.7毫米对6.2±2.8毫米；p = 0.004）。对仓储螨致敏与呼吸道症状的比例与对屋尘螨致敏相似（分别为51.8%和54.5%；p = 0.8527）。
在克罗地亚城市普通人群中，对非嗜皮螨科螨类的致敏比例与嗜皮螨科螨类相似，呼吸道症状范围相同。应考虑将仓储螨检测作为常规变应性诊断程序。
