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真性红细胞增多症患者的铁吸收:一项使用全身计数器和硫酸亚铁吸收试验的对比研究。

Iron absorption in patients with polycythemia vera: a comparative study using the whole-body counter and the ferrous sulfate absorption test.

作者信息

Schächner E, Ronen M, Pinkhas J, Djaldetti M

出版信息

Eur J Nucl Med. 1978 Apr 1;3(2):125-7. doi: 10.1007/BF00251637.

DOI:10.1007/BF00251637
PMID:108103
Abstract

The absorption of iron given per os to ten polycythemic patients was examined by two methods: first by giving radioactive iron (59Fe) and utilizing a whole-body counter, and second by peroral administration of ferrous sulfate. A correlation of 80% was achieved by the two methods. A comparison was made between the patterns of the ferrous sulfate absorption in the polycythemic patients and in five patients with low iron serum due to bleeding hemorrhoids. No difference was observed between these two groups, with the exception of the initial values which were lower in the polycythemic patients. On the other hand, the absorption of iron was higher in polycythemic patients, indicating that serum iron level is not the only factor regulating iron absorption.

摘要

采用两种方法检测了10例红细胞增多症患者口服铁剂后的吸收情况:第一种方法是给予放射性铁(59Fe)并使用全身计数器,第二种方法是口服硫酸亚铁。两种方法的相关性达到80%。对红细胞增多症患者和5例因痔疮出血导致血清铁含量低的患者的硫酸亚铁吸收模式进行了比较。除红细胞增多症患者的初始值较低外,两组之间未观察到差异。另一方面,红细胞增多症患者的铁吸收较高,这表明血清铁水平不是调节铁吸收的唯一因素。

相似文献

1
Iron absorption in patients with polycythemia vera: a comparative study using the whole-body counter and the ferrous sulfate absorption test.真性红细胞增多症患者的铁吸收:一项使用全身计数器和硫酸亚铁吸收试验的对比研究。
Eur J Nucl Med. 1978 Apr 1;3(2):125-7. doi: 10.1007/BF00251637.
2
Bioavailability of trivalent iron in oral iron preparations. Therapeutic efficacy and iron absorption from simple ferric compounds and high- or low-molecular weight ferric hydroxide-carbohydrate complexes.口服铁制剂中三价铁的生物利用度。简单铁化合物以及高分子量或低分子量氢氧化铁 - 碳水化合物复合物的治疗效果及铁吸收情况。
Arzneimittelforschung. 1975 Mar;25(3):420-6.
3
Correlation of postabsorptive serum iron increase and erythrocyte-59Fe-incorporation with the whole body retention of absorbed 59Fe.
Klin Wochenschr. 1982 Dec 15;60(24):1493-6. doi: 10.1007/BF01716100.
4
[Quantitative measurement of 59Fe-absorption. Comparison between iron labelled Parkevit-Fe and an iron-mono-preparation using a wholebody counter (author's transl)].
MMW Munch Med Wochenschr. 1981 Jan 30;123(5):181-3.
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Normal iron absorption determined by means of whole body counting and red cell incorporation of 59Fe.通过全身计数和59Fe的红细胞掺入法测定正常铁吸收。
Acta Med Scand. 1975 Oct;198(4):271-4. doi: 10.1111/j.0954-6820.1975.tb19539.x.
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Absorption from different types of iron tablets - correlation between serum iron increase in total absorption of iron.不同类型铁片的铁吸收——血清铁增加与铁总吸收之间的相关性。
Scand J Haematol Suppl. 1976;28:51-63. doi: 10.1111/j.1600-0609.1976.tb00348.x.
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Effects of some carbohydrates on iron absorption.某些碳水化合物对铁吸收的影响。
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Eur J Clin Pharmacol. 1982 Oct;23(4):335-8. doi: 10.1007/BF00613616.
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Iron absorption in early pregnancy - a study of the absorption of non-haeme iron and ferrous iron in early pregnancy.孕早期的铁吸收——一项关于孕早期非血红素铁和亚铁吸收情况的研究。
Acta Obstet Gynecol Scand Suppl. 1975;48:69-85. doi: 10.3109/00016347509156331.
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Absorption of slow-release iron and effects of ascorbic acid in normal subjects and after partial gastrectomy.正常受试者及部分胃切除术后受试者对缓释铁的吸收以及抗坏血酸的影响。
Br Med J. 1974 Nov 30;4(5943):505-8. doi: 10.1136/bmj.4.5943.505.

引用本文的文献

1
Dysregulated iron metabolism in polycythemia vera: etiology and consequences.真性红细胞增多症中铁代谢失调:病因与后果。
Leukemia. 2018 Oct;32(10):2105-2116. doi: 10.1038/s41375-018-0207-9. Epub 2018 Jul 24.

本文引用的文献

1
A NOTE CONCERNING THE "100 PER CENT VALUE" IN IRON ABSORPTION STUDIES BY WHOLE BODY COUNTING.
Blood. 1964 Jun;23:757-60.
2
The effect of iron stores on ferrokinetics in polycythaemia.铁储备对真性红细胞增多症中铁动力学的影响。
Br J Haematol. 1967 Nov;13(6):892-7. doi: 10.1111/j.1365-2141.1967.tb08859.x.
3
The use of a simple whole-body counter for haematological investigations.
Br J Haematol. 1966 May;12(3):276-82. doi: 10.1111/j.1365-2141.1966.tb05634.x.
4
Polycythaemia vera: differential diagnosis by ferrokinetic studies and treatment with busulphan (Myleran).
真性红细胞增多症:通过铁动力学研究进行鉴别诊断及使用白消安(马利兰)治疗
Br J Haematol. 1968 Apr;14(4):351-61. doi: 10.1111/j.1365-2141.1968.tb06987.x.
5
Polycythemia: a disease of all ages.红细胞增多症:一种各年龄段均可发生的疾病。
Geriatrics. 1974 Oct;29(10):124-34.