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自体红细胞与未成熟T细胞的结合。

Binding of autologous erythrocytes to immature T-cells.

作者信息

Charreire J, Bach J F

出版信息

Proc Natl Acad Sci U S A. 1975 Aug;72(8):3201-5. doi: 10.1073/pnas.72.8.3201.

DOI:10.1073/pnas.72.8.3201
PMID:1081228
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC432950/
Abstract

A small percentage of normal mouse thymus and spleen lymphocytes form rosettes with autologous erythrocytes. The number of these autologous rosettes increases 15- to 20-fold after adult thymectomy and to a lesser degree with aging. Autologous rosette level is also abnormally high in nude (congenitally athymic) mice. The high level of autologous rosette-forming cells found after adult thymectomy is normalized by injecting ng amounts of purified circulating thymic factor. Autologous rosette-forming cells adhere to nylon, belong to the less dense spleen cells, are in majority steroid-resistant in the thymus. All these properties suggest that autologous rosette-forming cells might belong to immature T-cell (thymic-dependent cell) precursors.

摘要

一小部分正常小鼠的胸腺和脾淋巴细胞能与自体红细胞形成玫瑰花结。成年胸腺切除术后，这些自体玫瑰花结的数量增加15至20倍，随着年龄增长增加幅度较小。裸鼠（先天性无胸腺）的自体玫瑰花结水平也异常高。成年胸腺切除术后发现的高水平自体玫瑰花结形成细胞，通过注射纳克量的纯化循环胸腺因子可恢复正常。自体玫瑰花结形成细胞能黏附于尼龙，属于密度较低的脾细胞，在胸腺中大多数对类固醇有抗性。所有这些特性表明，自体玫瑰花结形成细胞可能属于未成熟的T细胞（胸腺依赖性细胞）前体。

相似文献

1
Binding of autologous erythrocytes to immature T-cells.自体红细胞与未成熟T细胞的结合。
Proc Natl Acad Sci U S A. 1975 Aug;72(8):3201-5. doi: 10.1073/pnas.72.8.3201.
2
Studies on mouse auto-reactive cells. II. Cytotoxicity exerted by mouse lymphocytes against syngeneic erythrocytes.
Scand J Immunol. 1982 Jul;16(1):1-8. doi: 10.1111/j.1365-3083.1982.tb00692.x.
3
Morphological study of autologous rosettes (A-RFC).
Scand J Immunol. 1979;9(1):15-21. doi: 10.1111/j.1365-3083.1979.tb02701.x.
4
Antigen recognition by T lymphocytes. 3. Evidence for two populations of thymus-dependent rosette-forming cells in spleen and lymph nodes.T淋巴细胞的抗原识别。3. 脾脏和淋巴结中两类胸腺依赖性玫瑰花结形成细胞的证据。
Cell Immunol. 1973 Mar;6(3):394-406. doi: 10.1016/0008-8749(73)90039-7.
5
Studies on thymus products. I. Modification of rosette-forming cells by thymic extracts. Determination of the target RFC sub-population.胸腺产物的研究。I. 胸腺提取物对玫瑰花结形成细胞的修饰。靶玫瑰花结形成细胞亚群的测定。
Immunology. 1973 Sep;25(3):343-52.
6
The mechanism of interaction between T and B lymphocytes in the in vitro response to sheep erythrocytes. Non-specific collaboration across a dialysis membrane.T淋巴细胞与B淋巴细胞在体外对绵羊红细胞反应中的相互作用机制。通过透析膜的非特异性协作。
Immunology. 1975 Feb;28(2):253-69.
7
Properties of bispecific rosette-forming cells. II. --Rosette formation by "educated" T-lymphocytes.双特异性玫瑰花结形成细胞的特性。II. ——“受过训练的”T淋巴细胞形成玫瑰花结
Ann Immunol (Paris). 1975 Apr;126(3):303-17.
8
Interleukin-1 decreases the level of thymocytes forming rosettes with autologous erythrocytes: a new method of determination of interleukin-1 activity.
Arch Immunol Ther Exp (Warsz). 1987;35(3):371-9.
9
Demonstration and characterization of a serum factor produced by activated T cells.活化T细胞产生的一种血清因子的证明与特性分析
Immunology. 1977 Nov;33(5):643-51.
10
Age dependent reaction of mouse thymus cells with autologous and syngeneic erythrocytes.
Mech Ageing Dev. 1978 Nov;8(5):329-39. doi: 10.1016/0047-6374(78)90032-5.

引用本文的文献

1
Cellular basis of T-cell autoreactivity in autoimmune diseases.自身免疫性疾病中T细胞自身反应性的细胞基础。
Immunol Res. 1993;12(2):131-48. doi: 10.1007/BF02918300.
2
[Living Sézary cells in vitro: formation of autologous rosettes (author's transl)].体外活的赛塞里细胞：自体玫瑰花结的形成（作者译）
Arch Dermatol Res. 1980;269(3):261-8. doi: 10.1007/BF00406419.
3
Anti-self receptors. V. Properties of a mouse serum factor that blocks autorosetting receptors on lymphocytes.抗自身受体。V. 一种阻断淋巴细胞自身凝集受体的小鼠血清因子的特性。
Immunology. 1982 Feb;45(2):207-16.
4
Anti-self receptors. IV. H-2-restricted receptors on thymocytes recognize carbohydrate structures on target cells.抗自身受体。IV. 胸腺细胞上的H-2限制性受体识别靶细胞上的碳水化合物结构。
Immunogenetics. 1981 Mar 1;12(5-6):587-99. doi: 10.1007/BF01561699.
5
Human post-thymic precursor cells in health and disease. I. Characterization of the autologous rosette-forming T cells as post-thymic precursors.健康与疾病状态下的人类胸腺后前体细胞。I. 作为胸腺后前体的自身玫瑰花结形成T细胞的特征
Immunology. 1981 Jan;42(1):127-35.
6
Anti-self receptors. I. Direct detection of H-2L region-restricted receptors on murine thymocytes.抗自身受体。I. 小鼠胸腺细胞上H-2L区域限制性受体的直接检测。
J Exp Med. 1980 Mar 1;151(3):553-65. doi: 10.1084/jem.151.3.553.
7
Autologous rosette-forming T cells regulate responses of T cells. Phenotypic and functional analysis of suppressor cells generated from autologous rosette-forming T cells after autologous mixed lymphocyte reactions.自体玫瑰花结形成T细胞调节T细胞反应。自体混合淋巴细胞反应后自体玫瑰花结形成T细胞产生的抑制细胞的表型和功能分析。
J Clin Invest. 1981 Aug;68(2):356-64. doi: 10.1172/jci110263.
8
The serum thymic factor (FTS). Chemical and biological aspects.血清胸腺因子（FTS）。化学与生物学特性
Mol Cell Biochem. 1981 Dec 4;41:67-72. doi: 10.1007/BF00225298.
9
Immunoregulation in senescence: increased inducibility of antigen-specific suppressor T cells and loss of cell sensitivity to immunosuppression in aging mice.衰老过程中的免疫调节：衰老小鼠体内抗原特异性抑制性T细胞的诱导能力增强以及细胞对免疫抑制的敏感性丧失。
Proc Natl Acad Sci U S A. 1982 Jun;79(12):3803-7. doi: 10.1073/pnas.79.12.3803.
10
Anti-thyroglobulin antibodies induced with recombinant reovirus infection in BALB/c mice.重组呼肠孤病毒感染BALB/c小鼠诱导产生的抗甲状腺球蛋白抗体。
Immunology. 1990 Dec;71(4):581-5.

本文引用的文献

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Evidence for a small pool of immunocompetent cells in the mouse thymus.小鼠胸腺中存在少量免疫活性细胞的证据。
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Antigen recognition by T lymphocytes. II. Similar effects of azathioprine, antilymphocyte serum, and anti-theta serum on rosette-forming lymphocytes in normal and neonatally thymectomized mice.T淋巴细胞的抗原识别。II. 硫唑嘌呤、抗淋巴细胞血清和抗θ血清对正常及新生期胸腺切除小鼠中形成玫瑰花结的淋巴细胞的类似作用。
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Antigen-binding thymus-derived lymphocytes. I. Rapid method for isolation of theta-positive antigen-stimulated cells.抗原结合性胸腺衍生淋巴细胞。I. 分离θ阳性抗原刺激细胞的快速方法。
Immunology. 1972 Jun;22(6):959-65.
5
Antigen recognition by T lymphocytes. IV. Differences in antigen-binding characteristics of T- and B-RFC: a cause for variations in the evaluation of T-RFC.T淋巴细胞的抗原识别。IV. T和B淋巴细胞受体细胞（B-RFC）抗原结合特性的差异：T淋巴细胞受体细胞（T-RFC）评估差异的一个原因
Cell Immunol. 1973 Oct;9(1):32-44. doi: 10.1016/0008-8749(73)90165-2.
6
Studies on thymus products. IV. Absence of serum 'thymic activity' in adult NZB and (NZB x NZW) F1 mice.胸腺产物的研究。IV. 成年NZB和（NZB×NZW）F1小鼠血清中不存在“胸腺活性”
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Antigen recognition by T lymphocytes. 3. Evidence for two populations of thymus-dependent rosette-forming cells in spleen and lymph nodes.T淋巴细胞的抗原识别。3. 脾脏和淋巴结中两类胸腺依赖性玫瑰花结形成细胞的证据。
Cell Immunol. 1973 Mar;6(3):394-406. doi: 10.1016/0008-8749(73)90039-7.
8
Inhibition of in vitro autosensitization by a thymic humoral factor.胸腺体液因子对体外自身致敏的抑制作用。
Nat New Biol. 1973 Oct 24;245(147):253-5. doi: 10.1038/newbio245253a0.
9
Purification and biological activity of thymosin, a hormone of the thymus gland.胸腺素（一种胸腺分泌的激素）的纯化及生物活性
Proc Natl Acad Sci U S A. 1972 Jul;69(7):1800-3. doi: 10.1073/pnas.69.7.1800.
10
Studies on some physicochemical properties of a thymus humoral factor conferring immunocompetence on lymphoid cells.一种赋予淋巴细胞免疫活性的胸腺体液因子的某些理化性质研究。
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