Vincent J B
Department of Chemistry and Coalition for Biomolecular Products, University of Alabama, Tuscaloosa 35487-0336, USA.
Nutr Rev. 2000 Mar;58(3 Pt 1):67-72. doi: 10.1111/j.1753-4887.2000.tb01841.x.
Despite forty years of research on the potential role of chromium in carbohydrate and lipid metabolism, significant progress has only recently been made regarding the mode of action of chromium at a molecular level. The oligopeptide low-molecular-weight chromium-binding substance (LMWCr) may function as part of a novel insulin-signaling autoamplification mechanism. The proposed mechanism of action also sheds some light on the potential of chromium-containing compounds as nutritional supplements or in the treatment of adult-onset diabetes and other conditions. The potential relationship between the results of recent studies on diabetic patients and the proposed mode of action of LMWCr are discussed.
尽管对铬在碳水化合物和脂质代谢中的潜在作用进行了四十年的研究，但直到最近才在分子水平上取得了关于铬作用方式的重大进展。寡肽低分子量铬结合物质（LMWCr）可能作为一种新型胰岛素信号自动放大机制的一部分发挥作用。所提出的作用机制也为含铬化合物作为营养补充剂或用于治疗成年型糖尿病及其他病症的潜力提供了一些线索。本文讨论了近期对糖尿病患者的研究结果与所提出的LMWCr作用方式之间的潜在关系。
