Takasaki M, Konoshima T, Etoh H, Pal Singh I, Tokuda H, Nishino H
Kyoto Pharmaceutical University, Yamashina-ku, Kyoto, Japan.
Cancer Lett. 2000 Jul 3;155(1):61-5. doi: 10.1016/s0304-3835(00)00406-7.
In the course of our continuing search for novel cancer chemopreventive agents from natural sources, several kinds of Eucalyptus plants were screened. Consequently, the phlorogrucinol-monoterpene derivative, euglobal-G1 (EG-1), was obtained from the leaves of Eucalyptus grandis as an active constituent. EG-1 exhibited the remarkable inhibitory effect on two-stage carcinogenesis test of mouse skin tumors induced by 7, 12-dimethylbenz[a]anthracene (DMBA) as an initiator and fumonisin-B1, which has been known as one of mycotoxins produced by Fusarium monifliforme, as a promoter. Further, EG-1 exhibited potent anti-tumor-promoting activity on two-stage carcinogenesis test of mouse pulmonary tumor using 4-nitroquinoline-N-oxide (4-NQO) as an initiator and glycerol as a promoter.
在我们持续从天然来源寻找新型癌症化学预防剂的过程中，对几种桉树植物进行了筛选。结果，从巨桉树叶中获得了间苯三酚 - 单萜衍生物euglobal - G1（EG - 1）作为活性成分。EG - 1对由作为引发剂的7,12 - 二甲基苯并[a]蒽（DMBA）和作为促癌剂的伏马菌素 - B1（已知为由串珠镰刀菌产生的霉菌毒素之一）诱导的小鼠皮肤肿瘤的两阶段致癌试验表现出显著的抑制作用。此外，在以4 - 硝基喹啉 - N - 氧化物（4 - NQO）作为引发剂和甘油作为促癌剂的小鼠肺肿瘤两阶段致癌试验中，EG - 1表现出强大的抗肿瘤促进活性。
