越南人参（Panax vietnamensis）中人参皂苷-R2的癌症化学预防活性。

Cancer chemopreventive activity of majonoside-R2 from Vietnamese ginseng, Panax vietnamensis.

作者信息

Konoshima T, Takasaki M, Ichiishi E, Murakami T, Tokuda H, Nishino H, Duc N M, Kasai R, Yamasaki K

机构信息

Kyoto Pharmaceutical University, Japan.

出版信息

Cancer Lett. 1999 Dec 1;147(1-2):11-6. doi: 10.1016/s0304-3835(99)00257-8.

DOI:10.1016/s0304-3835(99)00257-8

PMID:10660083

Abstract

In the course of our continuing search for novel cancer chemopreventive agents from natural sources, several kinds of Panax plants were screened. Consequently, the ocotillol-type saponin, majonoside-R2 (MR2), was obtained from the rhizome and root of Panax vietnamensis (Vietnamese ginseng) as an active constituent. MR2 exhibited potent anti-tumor-promoting activity on two-stage carcinogenesis test of mouse hepatic tumor using N-nitrosodiethylamine (DEN) as an initiator and phenobarbital (PB) as a promoter. Further, MR2 exhibited the remarkable inhibitory effect on two-stage carcinogenesis test of mouse skin induced by nitric oxide (NO) donor/12-O-tetradecanoylphorbol-13-acetate (TPA) or peroxynitrite/TPA.

摘要

在我们持续从天然来源寻找新型癌症化学预防剂的过程中，对几种人参属植物进行了筛选。结果，从越南人参的根茎中获得了奥科梯隆型皂苷，人参皂苷-R2（MR2），作为一种活性成分。在以N-亚硝基二乙胺（DEN）为引发剂、苯巴比妥（PB）为促进剂的小鼠肝肿瘤两阶段致癌试验中，MR2表现出强大的抗肿瘤促进活性。此外，MR2在一氧化氮（NO）供体/十四烷酰佛波醇乙酯（TPA）或过氧亚硝酸盐/TPA诱导的小鼠皮肤两阶段致癌试验中表现出显著的抑制作用。