Wasserman J, Glas U, Blomgren H
Clin Exp Immunol. 1975 Mar;19(3):417-22.
Sera from a hundred patients with operable carcinoma of the breast and seventy-five age-matched controls were examined for antinuclear, smooth muscle, glomerular and mitochondrial antibodies by indirect immunofluorescence technique. Antinuclear and smooth muscle antibodies were found to be more frequent in cancer patients than in controls. The incidence of autoantibodies at the time the diagnosis was established was higher in patients who developed local recurrences or distant metastases within 2 years than in patients free from recurrence.
采用间接免疫荧光技术，对100例可手术乳腺癌患者及75例年龄匹配的对照者的血清进行抗核抗体、平滑肌抗体、肾小球抗体及线粒体抗体检测。结果发现，癌症患者中抗核抗体和平滑肌抗体的出现频率高于对照者。在确诊时即存在自身抗体的患者中，2年内发生局部复发或远处转移的患者比例高于无复发患者。
