癌症患者自身抗体的发生率。
Incidence of autoantibodies in cancer patients.
作者信息
Tannenberg A E, Muller H K, Cauchi M N, Nairn R C
出版信息
Clin Exp Immunol. 1973 Oct;15(2):153-6.
A review of the incidence of autoantibodies to normal tissue constituents in 250 patients with malignant disease has shown positive tests in 15% compared with 24% in patients with general non-neoplastic disorders and 8% in normal blood donors. In patients with lymphoma or leukaemia, the incidence of anti-smooth muscle antibodies was 15% compared with 4% in the control population; there was no increase in the incidence of anti-smooth muscle antibodies in patients with other malignant conditions. The incidence of anti-smooth muscle antibody in 4000 sera submitted for the investigation of possible autoimmune disorders is also reviewed. In our hands, autoantibodies to normal tissue components in patients with malignant tumours have not been a significant source of error in laboratory assessment of anti-tumour immunoreactivity.
对250例恶性疾病患者体内针对正常组织成分的自身抗体发生率进行的一项综述显示，15%的患者检测呈阳性，相比之下，患有一般非肿瘤性疾病的患者中这一比例为24%，正常献血者中为8%。在淋巴瘤或白血病患者中，抗平滑肌抗体的发生率为15%，而对照组人群中为4%；其他恶性疾病患者中抗平滑肌抗体的发生率没有增加。本文还综述了提交检测以排查可能的自身免疫性疾病的4000份血清中抗平滑肌抗体的发生率。在我们的研究中，恶性肿瘤患者体内针对正常组织成分的自身抗体并非实验室评估抗肿瘤免疫反应性时的一个重大误差来源。
Zotero 插件