Kintanar E B, Giordano T J, Thompson N W, Michael C W
Department of Pathology, University of Michigan Hospitals, Ann Arbor, Michigan 48109-0054, USA.
Diagn Cytopathol. 2000 Jun;22(6):379-82. doi: 10.1002/(sici)1097-0339(200006)22:6<379::aid-dc10>3.0.co;2-3.
We report on a case of extraluminal tracheal granular-cell tumor which was interpreted as a Hurthle-cell neoplasm of the thyroid on fine-needle aspirate. Review of the literature reveals only one other such case. The patient was a 35-yr-old female who presented with an enlarged thyroid. Aspiration cytology revealed a syncytium of cells with abundant granular cytoplasm interpreted as a thyroid follicular neoplasm with Hurthle-cell change. However, histology of the resection specimen with immunohistochemistry confirmed it as a granular-cell tumor. The cytologic differential diagnosis of neoplasms with oncocytoid cytoplasm in and around the thyroid should include granular-cell tumor of the trachea.
我们报告一例腔外气管颗粒细胞瘤，该病例在细针穿刺时被误诊为甲状腺许特莱细胞肿瘤。文献回顾显示仅有另外一例此类病例。患者为一名35岁女性，表现为甲状腺肿大。穿刺细胞学检查发现一群具有丰富颗粒状细胞质的细胞，被诊断为伴有许特莱细胞改变的甲状腺滤泡性肿瘤。然而，切除标本的组织学检查及免疫组化证实其为颗粒细胞瘤。甲状腺及其周围具有嗜酸性细胞质的肿瘤的细胞学鉴别诊断应包括气管颗粒细胞瘤。
