来自喜树（Himatanthus sucuuba）含三萜类化合物的乳汁的抗炎和镇痛活性。

Anti-inflammatory and analgesic activities of the latex containing triterpenes from Himatanthus sucuuba.

作者信息

de Miranda A L, Silva J R, Rezende C M, Neves J S, Parrini S C, Pinheiro M L, Cordeiro M C, Tamborini E, Pinto A C

出版信息

Planta Med. 2000 Apr;66(3):284-6. doi: 10.1055/s-2000-8572.

DOI:10.1055/s-2000-8572

Abstract

Some triterpenes and iridoids were previously isolated from the stem bark of Himatanthus sucuuba. The latex from Himatanthus sucuuba is used in popular amazonian medicine as an anti-inflammatory remedy. Fractions of the latex were pharmacologically evaluated with a view to verify this popular use in the carrageenan-induced rat paw edema and in the acetic acid-induced mouse constriction tests. The hexane fraction inhibited the edema formation by 35.9% at a dose of 200 mg/kg (p.o.) but no activity was observed at 100 mg/kg (p.o.). The triterpenes present in the hexane fraction were identified as lupeol acetate, alpha-amyrin and lupeol cinnamates. The fraction containing only cinnamates inhibited the edema and the abdominal constrictions by 50-40% and 57.9%, respectively, at 100 mg/kg (p.o.). Among all the fractions studied, the fraction containing only cinnamates showed the greatest anti-inflammatory activity which suggests that these compounds were responsible for the previously described activity of the crude extract.

摘要

一些三萜类化合物和环烯醚萜类化合物先前已从箭毒羊角拗的茎皮中分离出来。箭毒羊角拗的乳胶在亚马逊地区的传统医学中被用作抗炎药物。为了验证其在角叉菜胶诱导的大鼠足肿胀和乙酸诱导的小鼠扭体试验中的这种广泛应用，对乳胶的各个部分进行了药理学评估。己烷部分在剂量为200mg/kg（口服）时可抑制水肿形成35.9%，但在100mg/kg（口服）时未观察到活性。己烷部分中存在的三萜类化合物被鉴定为乙酸羽扇豆醇酯、α-香树脂醇和羽扇豆醇肉桂酸酯。仅含肉桂酸酯的部分在100mg/kg（口服）时分别抑制水肿和腹部收缩50 - 40%和57.9%。在所有研究的部分中，仅含肉桂酸酯的部分显示出最大的抗炎活性，这表明这些化合物是粗提物先前所述活性的原因。