Dobens L L, Raftery L A
Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown 02129, USA.
Dev Dyn. 2000 May;218(1):80-93. doi: 10.1002/(SICI)1097-0177(200005)218:1<80::AID-DVDY7>3.0.CO;2-8.
Drosophila oogenesis involves the coordinated development of germ cells and an overlying follicular epithelium. The follicle cells provide a genetically tractable system to investigate the cell biology of patterning and morphogenesis. Follicle cells initially form a cuboidal epithelium surrounding a syncytium of nurse cells and oocyte. Epithelial structure is maintained as these cells reorganize to create the three dimensional architecture of the eggshell. Both long-range and short-range cell-cell communications pattern the domains of follicle cells that will create specific eggshell structures. After terminal differentiation to deposit the eggshell proteins, the follicle cells die. This review summarizes recent progress in understanding the cell-cell communication that orchestrates follicle cell patterning and migrations. DE-cadherin-mediated adhesion is important at several steps in egg chamber formation and follicle cell migration. Notch signaling is critical during each successive round of patterning and migration. Integration of bone morphogenetic protein (BMP) and epidermal growth factor (EGF) signals patterns the elaborate structures of the dorsal-anterior eggshell.
果蝇卵子发生涉及生殖细胞与覆盖其上的卵泡上皮的协调发育。卵泡细胞提供了一个易于进行基因操作的系统，用于研究模式形成和形态发生的细胞生物学。卵泡细胞最初形成围绕着滋养细胞和卵母细胞合胞体的立方上皮。随着这些细胞重新组织以形成卵壳的三维结构，上皮结构得以维持。长距离和短距离的细胞间通讯决定了卵泡细胞的区域模式，这些区域将形成特定的卵壳结构。在终末分化以沉积卵壳蛋白后，卵泡细胞死亡。本综述总结了在理解协调卵泡细胞模式形成和迁移的细胞间通讯方面的最新进展。DE-钙黏蛋白介导的黏附在卵室形成和卵泡细胞迁移的几个步骤中都很重要。Notch信号在每一轮连续的模式形成和迁移过程中都至关重要。骨形态发生蛋白（BMP）和表皮生长因子（EGF）信号的整合决定了背前部卵壳的精细结构。
