[MAST-26的评估，一种新开发的用于检测IgE抗体的系统]

[Evaluation of MAST-26, newly developed system for the detection of IgE antibodies].

作者信息

Nakagawa T, Komase Y, Ikezawa Z, Aihara M, Iwasaki E, Okubo K, Hasegawa M, Akiyama K, Miyamoto T

机构信息

Dept. of Internal Medicine, St. Marianna University School of Medicine.

出版信息

Arerugi. 2000 Apr;49(4):335-44.

PMID:10824399

Abstract

MAST-26 is a new allergy testing system which allows simultaneous determination of allergen-specific IgE antibody levels for 26 allergens using 200 microliters of patient serum. To evaluate the effectiveness of MAST-26 for the detection of allergen-specific IgE antibody, a total of 100 serum samples were collected from allergic patients at five facilities, and allergen-specific IgE antibody was measured by MAST-26. 14% of them were positive to > or = 10 allergens. If the patients had severe allergic symptoms, they were likely to show positive to many allergens. A good correlation was found between the results obtained by MAST-26 with those measured by CAP RAST and by intradermal skin test. It was concluded that MAST-26 is an effective screening method for the detection of allergen-specific IgE.

摘要

MAST - 26是一种新型过敏检测系统，它能够使用200微升患者血清同时测定26种过敏原的特异性IgE抗体水平。为评估MAST - 26检测过敏原特异性IgE抗体的有效性，从五个机构的过敏患者中总共采集了100份血清样本，并通过MAST - 26测定过敏原特异性IgE抗体。其中14%的样本对≥10种过敏原呈阳性反应。如果患者有严重过敏症状，他们很可能对多种过敏原呈阳性反应。发现MAST - 26检测结果与CAP - RAST及皮内皮肤试验测定结果之间具有良好的相关性。得出结论，MAST - 26是检测过敏原特异性IgE的一种有效筛查方法。