Kuppers R C, Henney C S
J Exp Med. 1976 Mar 1;143(3):684-9. doi: 10.1084/jem.143.3.684.
The relationship between antigen recognition and lytic expression by effector T cells was examined by coculturing two cytolytically active lymphoid cell populations. When antigen recognition between the populations could occur only in one direction, then cytotoxicity was expressed only in that direction and the population whose antigens were recognized lost its lytic activity. In contrast, the cocultured effector cell population fully maintained its lytic potential. This lack of reciprocal inactivation was taken as evidence that T-cell receptor accomodation by surface antigen is linked to the expression of cytolytic activity by effector T lymphocytes.
通过将两个具有细胞溶解活性的淋巴细胞群体进行共培养，研究了效应T细胞的抗原识别与溶解活性表达之间的关系。当群体之间的抗原识别只能单向发生时，那么细胞毒性仅在该方向上表达，其抗原被识别的群体失去其溶解活性。相比之下，共培养的效应细胞群体完全保持其溶解潜力。这种缺乏相互失活的情况被视为表面抗原对T细胞受体的调节与效应T淋巴细胞溶解活性的表达相关的证据。
