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抗T细胞受体抗体对特异性细胞介导细胞毒性的抑制作用。

Inhibition of specific cell-mediated cytotoxicity by anti-T-cell receptor antibody.

作者信息

Kimura A K

出版信息

J Exp Med. 1974 Apr 1;139(4):888-901. doi: 10.1084/jem.139.4.888.

DOI:10.1084/jem.139.4.888
PMID:4131512
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2139562/
Abstract

The present study describes a method for the production of a specific anti-T-cell receptor antiserum, and characteristics of its ability to block specific cell-mediated cytotoxicity in vitro. Immunization and antiserum adsorption procedures were designed to select for idiotypic differences in the recognition units of C3H lymphocytes immune to two different strains of mouse cells, such that the reactivity of only one population of effector cells is inhibited by this antiserum. Both in vivo and in vitro sensitized effector T cells are subject to this inhibition. That the site of the antiserum blockade is clearly on the effector cell and not on the target cell is demonstrated.

摘要

本研究描述了一种制备特异性抗T细胞受体抗血清的方法，以及该抗血清在体外阻断特异性细胞介导的细胞毒性的能力特征。免疫和抗血清吸附程序的设计旨在选择对两种不同小鼠细胞株免疫的C3H淋巴细胞识别单位中的独特型差异，从而使该抗血清仅抑制一群效应细胞的反应性。体内和体外致敏的效应T细胞均受到这种抑制。结果表明，抗血清阻断的位点明确在效应细胞上，而非靶细胞上。

相似文献

1
Inhibition of specific cell-mediated cytotoxicity by anti-T-cell receptor antibody.抗T细胞受体抗体对特异性细胞介导细胞毒性的抑制作用。
J Exp Med. 1974 Apr 1;139(4):888-901. doi: 10.1084/jem.139.4.888.
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引用本文的文献

1
T cell receptors with allo-major histocompatibility complex specificity from rat and mouse. Similarity of size, plasmin susceptibility, and localization of antigen-binding region.具有大鼠和小鼠同种异体主要组织相容性复合体特异性的T细胞受体。大小、纤溶酶敏感性及抗原结合区域定位的相似性。
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Inhibition of the activity of cytotoxic murine T lymphocytes by antibodies to idiotypic determinants.抗独特型决定簇抗体对细胞毒性鼠T淋巴细胞活性的抑制作用。
Immunology. 1980 Jan;39(1):93-9.
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Cell-bound receptors for alloantigens on normal lymphocytes. II. Antialloantibody serum contains specific factors reacting with relevant immunocompetent T lymphocytes.正常淋巴细胞上同种异体抗原的细胞结合受体。II. 抗同种异体抗体血清含有与相关免疫活性T淋巴细胞发生反应的特异性因子。
J Exp Med. 1974 Sep 1;140(3):731-41. doi: 10.1084/jem.140.3.731.
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Surface glycoproteins of resting and activated human T lymphocytes.静息和活化的人T淋巴细胞的表面糖蛋白
Mol Cell Biochem. 1979 Oct 15;27(2):117-31. doi: 10.1007/BF00218355.
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Characterization of surface glycoproteins of mouse lymphoid cells.小鼠淋巴细胞表面糖蛋白的特性分析
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Mouse alloantibodies capable of blocking cytotoxic T-cell function. I. Relationship between the antigen reactive with blocking antibodies and the Lyt-2 locus.能够阻断细胞毒性T细胞功能的小鼠同种抗体。I. 与阻断抗体发生反应的抗原与Lyt-2基因座之间的关系。
J Exp Med. 1979 Sep 19;150(3):432-44. doi: 10.1084/jem.150.3.432.

本文引用的文献

1
ANTAGONISTIC EFFECTS OF HUMORAL ISOANTIBODIES ON THE IN VITRO CYTOTOXICITY OF IMMUNE LYMPHOID CELLS.体液同种抗体对免疫淋巴细胞体外细胞毒性的拮抗作用。
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Binding of radioiodinated bovine serum albumin to mouse spleen cells.放射性碘化牛血清白蛋白与小鼠脾细胞的结合。
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Specific inactivation of antigen-reactive cells with 125I-labelled antigen.用125I标记的抗原特异性灭活抗原反应性细胞。
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An extension of the 51Cr-release assay for the estimation of mouse cytotoxins.用于估计小鼠细胞毒素的51铬释放试验的扩展。
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Complex specificity of immune lymphocytes in allogeneic cell cultures.同种异体细胞培养中免疫淋巴细胞的复杂特异性
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6
Interaction of immune lymphocytes with the mixtures of target cells possessing selected specificities of the H-2 immunizing allele.免疫淋巴细胞与具有H-2免疫等位基因选定特异性的靶细胞混合物之间的相互作用。
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7
Receptors on immunocompetent cells. I. Receptor specificity of cells participating in a cellular immune response.免疫活性细胞上的受体。I. 参与细胞免疫应答的细胞的受体特异性。
Cell Immunol. 1970 Oct;1(4):404-18. doi: 10.1016/0008-8749(70)90017-1.
8
Antigen recognition: in vitro studies on the specificity of the cellular immune response.抗原识别：细胞免疫反应特异性的体外研究
J Exp Med. 1969 Nov 1;130(5):1031-45. doi: 10.1084/jem.130.5.1031.
9
[The effect of antibodies to gamma-globulin on the cytotoxic activity of immune lymphocytes in a culture of allogenic cells].[γ-球蛋白抗体对同种异体细胞培养中免疫淋巴细胞细胞毒性活性的影响]
Biull Eksp Biol Med. 1968 Dec;66(12):73-7.
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Blocking of the lymphocyte receptor site for cell mediated hypersensitivity and transplantation reactions by anti-light chain sera.抗轻链血清对细胞介导的超敏反应和移植反应中淋巴细胞受体部位的阻断作用。
Nature. 1969 May 31;222(5196):885-6. doi: 10.1038/222885a0.