Mascio A A, Ceglowski W S
Infect Immun. 1978 Feb;19(2):486-92. doi: 10.1128/iai.19.2.486-492.1978.
Infection of susceptible strains of mice with Friend leukemia virus (FLV) results in a profound depression of cell-mediated immunity as assessed by lymphocyte-mediated cytotoxicity. This depression occurs early in the disease, before the onset of splenomegaly, and is associated with a decline in the susceptibility of splenocytes from FLV-infected mice to lysis by anti-Thy-1. 2 serum and complement. Treatment of splenocytes from FLV-infected mice with neuraminidase restores, in large part, their susceptibility to anti-Thy-1.2 serum as well as their cytolytic capacity. These studies suggest that one early immunosuppressive consequence of infection with FLV involves alteration of the effector T-lymphocyte cell surface.
用弗瑞德白血病病毒（FLV）感染易感品系的小鼠，会导致细胞介导的免疫功能严重下降，这是通过淋巴细胞介导的细胞毒性来评估的。这种免疫抑制在疾病早期就会出现，在脾肿大出现之前，并且与感染FLV的小鼠脾细胞对抗Thy-1.2血清和补体裂解的敏感性下降有关。用神经氨酸酶处理感染FLV小鼠的脾细胞，在很大程度上恢复了它们对抗Thy-1.2血清的敏感性以及它们的细胞溶解能力。这些研究表明，感染FLV的一个早期免疫抑制后果涉及效应T淋巴细胞细胞表面的改变。
