Casey B, Hackett B P
Department of Pathology, Baylor College of Medicine, Texas Children's Hospital, Houston, 77030, USA.
Curr Opin Genet Dev. 2000 Jun;10(3):257-61. doi: 10.1016/s0959-437x(00)00085-x.
The study of left-right axis malformations in man and mouse has greatly advanced understanding of the mechanisms regulating vertebrate left-right axis formation. Recently, the roles of the TGF-beta family, Sonic hedgehog and fibroblast growth factor signaling, homeobox genes, and cilia in left-right axis determination have been more clearly defined. The identification of genes and environmental factors affecting left-right axis formation has important implications for understanding human laterality defects.
