Olding L B, Oldstone B A
J Immunol. 1976 Mar;116(3):682-6.
Lymphocytes from human newborns inhibit division of their mothers' lymphocytes. Three days after we cultured equal numbers of cells from a mother and her baby in the presence of PHA, mitosis of the mother's lymphocytes was suppressed 13-fold compared to that of the baby's lymphocytes. At the end of 3 days the number of baby's lymphocytes were doubled those of the mother's. The survival rates and mean mitotic indexes of both pairs of cell were roughly equivalent (mean +/- S.E: baby 2.4 +/- 0.8; mother 2.6 +/- 0.7), indicating that the lack of dividing lymphocytes from the mother was caused by inhibited division of the mother's lymphocytes, no enhanced growth of the newborn's cells. The cell population in newborns that is responsible for the inhibition effect resides in the T cell-enriched population. Lymphocytes from one newborn were not able to inhibit division of lymphocytes from another newborn, suggesting that lymphocytes from newborns could continue to divide despite their inhibitory effect. Other experiments showed that actively dividing fetal fibroblasts, amnion cells from the newborn, and continuous T lymphoblastoid cell lines were unable to inhibit mitosis of lymphocytes of the mother.
人类新生儿的淋巴细胞会抑制其母亲淋巴细胞的分裂。在有PHA存在的情况下，将一位母亲及其婴儿数量相等的细胞进行培养三天后，与婴儿的淋巴细胞相比，母亲的淋巴细胞有丝分裂被抑制了13倍。三天结束时，婴儿淋巴细胞的数量是母亲淋巴细胞数量的两倍。两组细胞的存活率和平均有丝分裂指数大致相当（平均值±标准误：婴儿2.4±0.8；母亲2.6±0.7），这表明母亲淋巴细胞缺乏分裂是由于母亲淋巴细胞的分裂受到抑制，而非新生儿细胞的生长增强。新生儿中负责这种抑制作用的细胞群体存在于富含T细胞的群体中。一名新生儿的淋巴细胞无法抑制另一名新生儿淋巴细胞的分裂，这表明新生儿的淋巴细胞尽管有抑制作用，但仍能继续分裂。其他实验表明，活跃分裂的胎儿成纤维细胞、新生儿的羊膜细胞以及连续的T淋巴母细胞系均无法抑制母亲淋巴细胞的有丝分裂。
