人新生儿T细胞发挥抑制作用对OKT8 +抑制性细胞增殖的需求。
Requirement for OKT8+ suppressor cell proliferation for suppression by human newborn T cells.
作者信息
Hayward A R, Merrill D
出版信息
Clin Exp Immunol. 1981 Sep;45(3):468-74.
Abstract
The percentage of cells bearing the suppressor phenotype OKT8+increases in PWM-stimulated cultures of human newborn lymphocytes. Prevention of this increase either by adding 50 microM deoxyguanosine to the cultures of by pretreating the newborn cells with OKT8 and complement reduced the suppressor activity of newborn T cells. These results suggest that newborn T cells are not intrinsically suppressive, but that they become so in vitro after stimulation by PWM.
摘要
在人新生儿淋巴细胞经PWM刺激的培养物中，具有抑制性表型OKT8 +的细胞百分比增加。通过向培养物中添加50微摩尔脱氧鸟苷或用OKT8和补体预处理新生儿细胞来阻止这种增加，可降低新生儿T细胞的抑制活性。这些结果表明，新生儿T细胞并非固有地具有抑制性，而是在体外经PWM刺激后才具有抑制性。
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