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人新生儿T细胞发挥抑制作用对OKT8 +抑制性细胞增殖的需求。

Requirement for OKT8+ suppressor cell proliferation for suppression by human newborn T cells.

作者信息

Hayward A R, Merrill D

出版信息

Clin Exp Immunol. 1981 Sep;45(3):468-74.

PMID:6461445
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1537415/
Abstract

The percentage of cells bearing the suppressor phenotype OKT8+increases in PWM-stimulated cultures of human newborn lymphocytes. Prevention of this increase either by adding 50 microM deoxyguanosine to the cultures of by pretreating the newborn cells with OKT8 and complement reduced the suppressor activity of newborn T cells. These results suggest that newborn T cells are not intrinsically suppressive, but that they become so in vitro after stimulation by PWM.

摘要

在人新生儿淋巴细胞经PWM刺激的培养物中，具有抑制性表型OKT8 +的细胞百分比增加。通过向培养物中添加50微摩尔脱氧鸟苷或用OKT8和补体预处理新生儿细胞来阻止这种增加，可降低新生儿T细胞的抑制活性。这些结果表明，新生儿T细胞并非固有地具有抑制性，而是在体外经PWM刺激后才具有抑制性。

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2
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本文引用的文献

1
Newborn T cell suppression: early appearance, maintenance in culture, and lack of growth factor suppression.新生儿T细胞抑制：早期出现、在培养中的维持以及生长因子抑制的缺乏。
J Immunol. 1981 Jan;126(1):50-3.
2
Functional analysis of human T cell subsets defined by monoclonal antibodies. I. Collaborative T-T interactions in the immunoregulation of B cell differentiation.由单克隆抗体定义的人T细胞亚群的功能分析。I. B细胞分化免疫调节中的T-T协作相互作用。
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Plaque-forming cells in human cord blood: studies on T and B cell function.人脐带血中的噬斑形成细胞：T细胞和B细胞功能研究
Clin Exp Immunol. 1980 Jul;41(1):176-81.
5
Precursor and effector phenotypes of activated human T lymphocytes.活化的人T淋巴细胞的前体和效应表型。
Nature. 1980 Nov 27;288(5789):391-3. doi: 10.1038/288391a0.
6
Inhibition of suppressor T-cell development following deoxyguanosine administration.给予脱氧鸟苷后抑制抑制性T细胞的发育。
Nature. 1980 Jun 12;285(5765):494-6. doi: 10.1038/285494a0.
7
Current concepts in immunology: Regulation of the immune response--inducer and suppressor T-lymphocyte subsets in human beings.免疫学的当前概念：免疫应答的调节——人类中的诱导性和抑制性T淋巴细胞亚群。
N Engl J Med. 1980 Aug 14;303(7):370-3. doi: 10.1056/NEJM198008143030704.
8
Induction of suppression through human T cell interactions.通过人类T细胞相互作用诱导抑制作用。
Clin Exp Immunol. 1980 Feb;39(2):496-502.
9
A monoclonal antibody reactive with the human cytotoxic/suppressor T cell subset previously defined by a heteroantiserum termed TH2.一种单克隆抗体，可与人细胞毒性/抑制性T细胞亚群发生反应，该亚群先前由一种名为TH2的异种抗血清所定义。
J Immunol. 1980 Mar;124(3):1301-7.
10
B cell differentiation and immunoregulatory T cell function in human cord blood lymphocytes.人类脐带血淋巴细胞中的B细胞分化及免疫调节性T细胞功能
J Clin Invest. 1980 Aug;66(2):383-8. doi: 10.1172/JCI109867.