Touza Rey F, Martínez Vázquez C, Alonso Alonso J, Méndez Piñeiro M J, Rubianes González M, Crespo Casal M
Unidad de Enfermedades Infecciosas, Complejo Hospitalario Xeral-Cies, Facultad de Medicina de Santiago, Vigo.
An Med Interna. 2000 Feb;17(2):86-7.
Chronic granulomatous disease (CGD) is an heterogeneous inherited disorder where the microbicidal phagocytic properties of leukocytes are impaired. Patients with CGD are prone to severe ious with many microorganisms such as Aspergillus spp (1,2). Recently, interferon gamma (IFN-8) which significantly reduces the frequency of infections in these patients, has been proved useful (3,4). We present our experience with the clinical use of these cytoscine. A 26-year-old woman with CGD suffered recement multiple brain abscesses by Aspergillus fumigatus treated in many occasions with surgical drainage. Since treatment with IFN-8 was started, two years ago, she is well and asymptomatic until the moment.
慢性肉芽肿病（CGD）是一种异质性遗传性疾病，其中白细胞的杀菌吞噬特性受损。CGD患者容易受到许多微生物（如曲霉菌属）的严重感染（1,2）。最近，已证明干扰素γ（IFN-8）可显著降低这些患者的感染频率，是有用的（3,4）。我们介绍我们在这些细胞因子临床应用方面的经验。一名26岁的CGD女性患者多次因烟曲霉导致脑脓肿，曾多次接受手术引流治疗。自从两年前开始使用IFN-8治疗以来，她目前情况良好且无症状。
