Forsberg F, Liu J B, Chiou H J, Rawool N M, Parker L, Goldberg B B
Department of Radiology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Ultrasonics. 2000 Mar;38(1-8):110-3. doi: 10.1016/s0041-624x(99)00149-3.
Wideband harmonic imaging (with phase inversion for improved tissue suppression) was compared to fundamental imaging in vivo. Four woodchucks with naturally occurring liver tumors were injected with Imagent (Alliance Pharmaceutical Corp., San Diego, CA). Randomized combinations of dose (0.05, 0.2 and 0.4 ml/kg) and acoustic output power (AO; 5, 25 and 63% or MI < or = 0.9) were imaged in gray scale using a Sonoline Elegra scanner (Siemens Medical Systems, Issaquah, WA). Tumor vascularity, conspicuity and contrast enhancement were rated by three independent observers. Imagent produced marked tumor enhancement and improved depiction of neovascularity at all dosages and AO settings in both modes. Tumor vascularity and enhancement correlated with mode, dose and AO (P < 0.002). Fundamental imaging produced more enhancement (P < 0.05), but tumor vascularity and conspicuity were best appreciated in harmonic mode (P < 0.05). Under the conditions studied here, the best approach was wideband harmonic imaging with 0.2 ml/kg of Imagent at an AO of 25%.
将宽带谐波成像（采用相位反转以增强组织抑制效果）与体内基波成像进行了比较。对四只患有自然发生的肝肿瘤的土拨鼠注射了Imagent（Alliance制药公司，加利福尼亚州圣地亚哥）。使用Sonoline Elegra扫描仪（西门子医疗系统公司，华盛顿州伊斯萨夸）以灰度模式对剂量（0.05、0.2和0.4 ml/kg）和声输出功率（AO；5%、25%和63%或MI≤0.9）的随机组合进行成像。由三名独立观察者对肿瘤血管、清晰度和对比增强进行评分。在两种模式下，所有剂量和AO设置下，Imagent均产生明显的肿瘤增强并改善了新生血管的显示。肿瘤血管和增强与模式、剂量和AO相关（P<0.002）。基波成像产生的增强更多（P<0.05），但谐波模式下肿瘤血管和清晰度最佳（P<0.05）。在此处研究的条件下，最佳方法是使用0.2 ml/kg的Imagent在25%的AO下进行宽带谐波成像。
