al-Nuaim A R, Abdullah M A, Stevens B, Zain M
Department of Medicine, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia.
Indian J Pediatr. 1995 Sep-Oct;62(5):605-9. doi: 10.1007/BF02761890.
Blood samples from 813 newborns were spotted on to filter paper and the 17-hydroxyprogesterone concentration was measured using the Delfia (R) fluorometric immunoassay. The median, mean, and standard deviation (SD) for the total population were 20, 21 and (11) nmol/L respectively. Males had significantly higher levels than females with median, mean and (SD) of 22, 22 and (12) nmol/L. Similarly, low birth weight babies were found to have significantly higher levels than normal birth weight babies with median, mean and (SD) of 21, 24 (12) nmol/L. Preterm babies were also found to have significantly higher levels than full term babies, with median, mean and (SD) of 25, 29 (16) nmol/L. As experienced elsewhere, those factors should be taken into consideration when considering a cut-off point in any neonatal screening program for congenital adrenal hyperplasia.
采集了813名新生儿的血样，滴在滤纸上，采用Delfia®荧光免疫分析法测定17 - 羟孕酮浓度。总体人群的中位数、均值和标准差（SD）分别为20、21和11 nmol/L。男性的水平显著高于女性，中位数、均值和（SD）分别为22、22和12 nmol/L。同样，低出生体重儿的水平显著高于正常出生体重儿，中位数、均值和（SD）分别为21、24（12）nmol/L。还发现早产儿的水平显著高于足月儿，中位数、均值和（SD）分别为25、2９（16）nmol/L。正如在其他地方所经历的那样，在任何先天性肾上腺皮质增生症新生儿筛查项目中考虑临界值时，都应考虑这些因素。
