新生儿血浆17-羟孕酮浓度
Plasma 17OH-progesterone concentrations in newborn infants.
作者信息
Hughes I A, Riad-Fahmy D, Griffiths K
出版信息
Arch Dis Child. 1979 May;54(5):347-9. doi: 10.1136/adc.54.5.347.
Abstract
Plasma concentrations of 17OH-progesterone were determined in 60 normal newborn infants aged between 3 and 36 hours. Mean levels decreased rapidly during this time after removal of the placental contribution of this steroid. A further 70 normal infants, studied between ages 2 and 7 days, showed a mean plasma 17OH-progesterone concentration of 3.5 nmol/1 (1.2 ng/ml). By comparison, plasma concentrations in untreated infants with congenital adrenal hyperplasia were markedly raised. At 36 hours of age, there was an obvious difference between plasma levels of this steroid in normal and affected infants. Determination of plasma 17OH-progesterone concentrations are valuable in the evaluation of disorders of sexual differentiation and electrolyte balance in newborn infants, provided due care is given to the timing of sample collections.
摘要
测定了60名年龄在3至36小时之间的正常新生儿的血浆17-羟孕酮浓度。在去除该类固醇的胎盘来源后，这段时间内平均水平迅速下降。另外70名年龄在2至7天之间的正常婴儿，其血浆17-羟孕酮平均浓度为3.5 nmol/1（1.2 ng/ml）。相比之下，未经治疗的先天性肾上腺皮质增生症婴儿的血浆浓度明显升高。在36小时龄时，正常婴儿和患病婴儿的该类固醇血浆水平存在明显差异。只要对样本采集时间给予适当注意，测定血浆17-羟孕酮浓度对于评估新生儿性分化和电解质平衡紊乱很有价值。
相似文献
1
Plasma 17OH-progesterone concentrations in newborn infants.新生儿血浆17-羟孕酮浓度
Arch Dis Child. 1979 May;54(5):347-9. doi: 10.1136/adc.54.5.347.
2
The application of a serum 17OH-progesterone radioimmunoassay to the diagnosis and management of congenital adrenal hyperplasia.血清17-羟孕酮放射免疫测定法在先天性肾上腺皮质增生症诊断和治疗中的应用。
J Pediatr. 1976 May;88(5):766-73. doi: 10.1016/s0022-3476(76)81112-2.
3
Early diagnosis of congenital adrenal hyperplasia by measurement of 17-hydroxyprogesterone.
Clin Endocrinol (Oxf). 1975 Jul;4(4):451-54. doi: 10.1111/j.1365-2265.1975.tb01553.x.
4
Plasma 17-hydroxyprogesterone in newborn infants with congenital adrenal hyperplasia and in infants with normal adrenal function.先天性肾上腺皮质增生症新生儿及肾上腺功能正常婴儿的血浆17-羟孕酮水平
Arch Dis Child. 1974 Mar;49(3):192-4. doi: 10.1136/adc.49.3.192.
5
The relationships between serum concentrations of 17OH-progesterone and other serum and urinary steroids in patients with congenital adrenal hyperplasia.
J Clin Endocrinol Metab. 1978 Jan;46(1):98-104. doi: 10.1210/jcem-46-1-98.
6
The role of serum 17 alpha-hydroxy progesterone in the diagnosis of virilizing congenital adrenal hyperplasia.
Aust Paediatr J. 1977 Mar;13(1):12-6. doi: 10.1111/j.1440-1754.1977.tb01889.x.
7
8
Postnatal changes in blood spot 17-hydroxyprogesterone level in healthy preterm and full-term neonates.健康早产儿和足月儿血斑17-羟孕酮水平的产后变化。
Acta Paediatr Hung. 1988;29(3-4):239-43.
9
Gas-liquid chromatography in the diagnosis of congenital adrenal hyperplasia.
J Steroid Biochem. 1974 Aug;5(5):467-9. doi: 10.1016/0022-4731(74)90045-4.
10
Plasma progesterone and 17-hydroxyprogesterone in normal men and children with congenital adrenal hyperplasia.正常男性及先天性肾上腺皮质增生症儿童的血浆孕酮和17-羟孕酮
J Clin Invest. 1969 May;48(5):930-9. doi: 10.1172/JCI106052.
引用本文的文献
1
Estradiol and progesterone strongly inhibit the innate immune response of mononuclear cells in newborns.雌二醇和孕酮强烈抑制新生儿单核细胞的固有免疫反应。
Infect Immun. 2011 Jul;79(7):2690-8. doi: 10.1128/IAI.00076-11. Epub 2011 Apr 25.
2
Effect of gender, birth weight and gestational age on serum 17-hydroxyprogesterone concentration and distribution among neonates in Saudi Arabia.性别、出生体重和胎龄对沙特阿拉伯新生儿血清17-羟孕酮浓度及分布的影响。
Indian J Pediatr. 1995 Sep-Oct;62(5):605-9. doi: 10.1007/BF02761890.
3
Plasma 17-hydroxyprogesterone concentrations in ill newborn infants.患病新生儿的血浆17-羟孕酮浓度
Arch Dis Child. 1983 Jul;58(7):532-4. doi: 10.1136/adc.58.7.532.
4
Measurement of urine 17-oxogenic steroids, 17-hydroxycorticosteroids, and 17-oxosteroids has been superseded by better tests.尿17-生氧类固醇、17-羟皮质类固醇和17-氧类固醇的测定已被更好的检测方法所取代。
Br Med J (Clin Res Ed). 1985 Sep 21;291(6498):805-6. doi: 10.1136/bmj.291.6498.805.
5
Should we screen for congenital adrenal hyperplasia? A review of 117 cases.我们应该筛查先天性肾上腺增生症吗？117例病例回顾。
Arch Dis Child. 1987 Jul;62(7):659-62. doi: 10.1136/adc.62.7.659.
6
Prenatal diagnosis of congenital adrenal hyperplasia: reliability of amniotic fluid steroid analysis.先天性肾上腺皮质增生症的产前诊断：羊水类固醇分析的可靠性
J Med Genet. 1987 Jun;24(6):344-7. doi: 10.1136/jmg.24.6.344.
7
Unusual dual genital duct remnants in true hermaphroditism.真两性畸形中不寻常的双生殖管道残留
J Med Genet. 1988 Mar;25(3):206-8. doi: 10.1136/jmg.25.3.206.
8
Clinical aspects of congenital adrenal hyperplasia: early diagnosis and prognosis.
J Inherit Metab Dis. 1986;9 Suppl 1:115-23. doi: 10.1007/BF01800865.
9
Management of congenital adrenal hyperplasia.先天性肾上腺皮质增生症的管理
Arch Dis Child. 1988 Nov;63(11):1399-404. doi: 10.1136/adc.63.11.1399.
10
Response to ACTH in the newborn.新生儿对促肾上腺皮质激素的反应。
Arch Dis Child. 1986 Jan;61(1):57-60. doi: 10.1136/adc.61.1.57.
本文引用的文献
1
Sources of plasma 17alpha-hydroxyprogesterone in human pregnancy.
J Clin Endocrinol Metab. 1972 Dec;35(6):799-808. doi: 10.1210/jcem-35-6-799.
2
Serum 17-alpha-hydroxyprogesterone, progesterone, estradiol, and testosterone in the diagnosis and management of congenital adrenal hyperplasia.血清17-α-羟孕酮、孕酮、雌二醇和睾酮在先天性肾上腺皮质增生症的诊断与管理中的应用
J Pediatr. 1974 Dec;85(6):782-7. doi: 10.1016/s0022-3476(74)80340-9.
3
Diagnosis of congenital adrenal hyperplasia by measurement of plasma 17-hydroxyprogesterone.通过检测血浆17-羟孕酮诊断先天性肾上腺皮质增生症。
Arch Dis Child. 1972 Feb;47(251):62-5. doi: 10.1136/adc.47.251.62.
4
The application of a serum 17OH-progesterone radioimmunoassay to the diagnosis and management of congenital adrenal hyperplasia.血清17-羟孕酮放射免疫测定法在先天性肾上腺皮质增生症诊断和治疗中的应用。
J Pediatr. 1976 May;88(5):766-73. doi: 10.1016/s0022-3476(76)81112-2.
5
Pituitary-gonadal relations in infancy: 2. Patterns of serum gonadal steroid concentrations in man from birth to two years of age.
J Clin Endocrinol Metab. 1976 Apr;42(4):679-86. doi: 10.1210/jcem-42-4-679.
6
Early diagnosis of salt-losing congenital adrenal hyperplasia in a newborn boy.新生儿男婴失盐型先天性肾上腺皮质增生症的早期诊断
Can Med Assoc J. 1977 Aug 20;117(4):363-5.
7
Ontogenic study of plasma 17alpha-hydroxyprogesterone in the human. I. Postnatal period: evidence for a transient ovarian activity in infancy.
Pediatr Res. 1978 Jan;12(1):6-11. doi: 10.1203/00006450-197801000-00003.
8
Internal quality control of radioimmunoassays.
J Endocrinol. 1978 Feb;76(2):203-10. doi: 10.1677/joe.0.0760203.
9
Longitudinal studies of plasma aldosterone, corticosterone, deoxycorticosterone, progesterone, 17-hydroxyprogesterone, cortisol, and cortisone determined simultaneously in mother and child at birth and during the early neonatal period. I. Spontaneous delivery.对母亲和孩子在出生时及新生儿早期同时进行的血浆醛固酮、皮质酮、脱氧皮质酮、孕酮、17-羟孕酮、皮质醇和可的松的纵向研究。I. 自然分娩。
J Clin Endocrinol Metab. 1978 Jun;46(6):971-85. doi: 10.1210/jcem-46-6-971.
10
Early diagnosis of congenital adrenal hyperplasia by measurement of 17-hydroxyprogesterone.
Clin Endocrinol (Oxf). 1975 Jul;4(4):451-54. doi: 10.1111/j.1365-2265.1975.tb01553.x.
Zotero 插件