使用滤纸血斑中的17-羟孕酮检测法对先天性肾上腺皮质增生症进行新生儿筛查。
Neonatal screening for congenital adrenal hyperplasia using 17-hydroxyprogesterone assay in filter paper blood spots.
作者信息
Larsson A, Hagenfeldt L, von Döbeln U, Curstedt T, Gustafsson J, Svensson E
机构信息
Department of Bacteriology, National Bacteriological Laboratory, Stockholm, Sweden.
出版信息
Horm Res. 1988;30(6):235-40. doi: 10.1159/000181069.
PMID:3250925
Abstract
Screening of infants for congenital adrenal hyperplasia (CAH) using filter paper blood samples collected on the 5th day of life was performed with a radioimmunoassay for 17-hydroxyprogesterone without extraction with organic solvents. A total of 153,000 newborns were screened and 12 cases of CAH were detected (1:12,800). With recall levels related to gestational age, the recall rate could be lowered to 0.05%.
摘要
使用出生第5天采集的滤纸血样，通过无需有机溶剂萃取的17-羟孕酮放射免疫测定法对婴儿进行先天性肾上腺皮质增生症（CAH）筛查。共筛查了153,000名新生儿，检测出12例CAH（1:12,800）。根据与胎龄相关的召回水平，召回率可降至0.05%。
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