[被动免疫对适应性免疫模型免疫抑制作用的研究]

[Study of the immunodepressive effect of passive immunization on a model of adaptive immunity].

作者信息

Korshunov V M, Kudriashov V M, Kalinkovich A G, Pinegin B V, Uteshev B S

出版信息

Zh Mikrobiol Epidemiol Immunobiol. 1975 Apr(4):53-7.

Abstract

The effect of various doses of specific serum administered in passive immunization on the formation of primary and secondary adaptive immunity in mice of the CBA strain was studied. Primary and secondary response was more sensitive to passive immunization on a model of adaptive immunity than in vivo. Most sensitive to the immunodepressive action of specific antibodies IgM and IgG were plaque-forming cells, and most resistant -- rosette-forming cells and cells. This led to a supposition that antibodies administered in passive immunization depressed the development of the immunological response acting at the level of T- and B cells.

摘要

研究了在被动免疫中给予不同剂量的特异性血清对CBA品系小鼠初次和二次适应性免疫形成的影响。在适应性免疫模型中，初次和二次反应对被动免疫比在体内更敏感。对特异性抗体IgM和IgG的免疫抑制作用最敏感的是形成噬斑细胞，最具抗性的是形成玫瑰花结细胞和细胞。这导致一种推测，即在被动免疫中给予的抗体通过作用于T细胞和B细胞水平来抑制免疫反应的发展。