乙肝表面抗原阳性献血者中的乙肝e抗原和抗体
Hepatitis Be antigen and antibody in hepatitis B surface antigen positive blood donors.
作者信息
Barr A, Black S H, Burrell C J, Dow B, Macvarish I
出版信息
J Clin Pathol. 1979 Feb;32(2):132-5. doi: 10.1136/jcp.32.2.132.
In a study of 105 asymptomatic HBsAg positive blood donors, 9 (8.6%) were found to have HBeAg, 38 (36.2%) anti-HBe, and the remaining 58 (55.2%) neither marker detectable by gel diffusion. There was no correlation between HBeAg/anti-HBe status and HBsAg sub-types, Glm allotypes, the presence of anti-Gm, red cell antibodies, or rheumatoid factor. Rheumatoid factor activity could be removed from anti-HBe positive sera without removing anti-HBe activity, indicating that separate entities were involved. HBeAg was found only in donors under the age of 30 (P less than 0.005), while anti-HBe did not show an age-related trend. HBeAg was also found less commonly in donors of blood group A than in the total carrier population (P less than 0.05), indicating an apparent protection in carriers of group A. The blood group distribution for the 105 HBsAg positive donors was similar to that of the general population.
在一项针对105名无症状HBsAg阳性献血者的研究中，发现9名（8.6%）有HBeAg，38名（36.2%）有抗-HBe，其余58名（55.2%）通过凝胶扩散法均未检测到这两种标志物。HBeAg/抗-HBe状态与HBsAg亚型、GIm同种异型、抗-Gm的存在、红细胞抗体或类风湿因子之间无相关性。类风湿因子活性可从抗-HBe阳性血清中去除，而不影响抗-HBe活性，这表明涉及不同的实体。仅在30岁以下的献血者中发现HBeAg（P<0.005），而抗-HBe未显示出与年龄相关的趋势。在A型血献血者中发现HBeAg的情况也比在整个携带者群体中少见（P<0.05），这表明A型血携带者有明显的保护作用。105名HBsAg阳性献血者的血型分布与普通人群相似。
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