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铅中毒——一种常见儿童症状的模仿者。

Plumbism--a mimicker of common childhood symptoms.

作者信息

Kalra V, Gulati S, Chitralekha K T, Pande P, Makhijani S D, Sharma C S

机构信息

Department of Pediatrics, All India Institute of Medical Sciences, New Delhi.

出版信息

Indian J Pediatr. 2000 Feb;67(2):81-6. doi: 10.1007/BF02726170.

Abstract

Lead poisoning is a preventable entity that can affect almost every system of the body. Its toxic effects range from subtle common childhood symptoms to even death. In a prospective study forty six children with at least one symptom compatible with plumbism were enrolled after screening patients attending medical services at AIIMS. The work-up included a detailed clinical history and examination including intelligence quotient (IQ) and behaviour. Blood lead levels were estimated in all with due precautions. Their ages ranged from 2.5 to 18 years and M:F ratio was 2:1. The common symptoms included unexplained recurrent colic (39), anorexia (21), sporadic vomiting and constipation (13), pigmented gum lines (11), growth failure (11), history of pica (9) etc. None of the children had acceptable blood lead levels (< 10 micrograms/dl). Ninety three per cent children had levels > 20 micrograms/dl and 47.8% had > 45 micrograms/dl. Statistically significant correlation with blood lead levels was seen with most symptoms. Plumbism can mimic common childhood illnesses and should be investigated in children with a clinically compatible profile. Community awareness with regard to pica reduction may be an important preventive measure. This silent epidemic needs to be aggressively tackled by a multipronged approach.

摘要

铅中毒是一种可预防的病症,它几乎会影响身体的每个系统。其毒性作用范围从儿童常见的轻微症状到甚至死亡。在一项前瞻性研究中,对在全印度医学科学研究所(AIIMS)接受医疗服务的患者进行筛查后,纳入了46名至少有一项与铅中毒相符症状的儿童。检查包括详细的临床病史和检查,包括智商(IQ)和行为评估。所有患者均采取适当预防措施后测定血铅水平。他们的年龄在2.5至18岁之间,男女比例为2:1。常见症状包括不明原因的反复腹痛(39例)、厌食(21例)、偶发性呕吐和便秘(13例)、牙龈色素沉着(11例)、生长发育迟缓(11例)、异食癖病史(9例)等。没有一个儿童的血铅水平处于可接受范围(<10微克/分升)。93%的儿童血铅水平>20微克/分升,47.8%的儿童血铅水平>45微克/分升。大多数症状与血铅水平存在统计学上的显著相关性。铅中毒可能会模仿儿童常见疾病,对于临床表现相符的儿童应进行调查。减少异食癖的社区宣传可能是一项重要的预防措施。这种悄无声息的流行病需要通过多管齐下的方法积极应对。

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