Bessonova E N, Lesniak O M, Podymova S D, Bazarnyĭ V V
Klin Med (Mosk). 2000;78(4):36-40.
The study is based on the study of data on 33 patients with Lyme Borrelia infection in the presence of typical erythema migrans in whom elevated levels of serum bilirubin or transaminases were detected simultaneously with erythema or just shortly. The obligatory criterion was no history evidence of hepatitis and abnormal hepatic functional tests. Higher levels of serum aminotransferases were a major manifestation of Lyme hepatitis in the Sverdlovsk region. In 32 patients, ALT was increased, on the average, up to 176 U/l, and AST activity was up to 113 U/l within the first 2 weeks of the disease in the absence of clinical manifestations of hepatic and biliary diseases. There were changes in the levels of serum transaminases and bilirubin following 3- and 8-month antibiotic therapy. The presence of viruses A and C in moderate chronic hepatitis induced long-term increases in the activity of transaminases in 3 cases, as evidenced by histological studies of hepatic biopsy specimens.
该研究基于对33例莱姆疏螺旋体感染患者的数据研究，这些患者均出现典型游走性红斑，且在出现红斑时或之后不久检测到血清胆红素或转氨酶水平升高。必要标准是无肝炎病史证据且肝功能检查正常。血清转氨酶水平升高是斯维尔德洛夫斯克地区莱姆肝炎的主要表现。在32例患者中，在疾病的前两周内，谷丙转氨酶（ALT）平均升高至176 U/L，谷草转氨酶（AST）活性升高至113 U/L，且无肝胆疾病的临床表现。在进行3个月和8个月的抗生素治疗后，血清转氨酶和胆红素水平发生了变化。中度慢性肝炎中A、C型病毒的存在导致3例患者转氨酶活性长期升高，肝活检标本的组织学研究证实了这一点。
