细胞表面免疫球蛋白。十八。携带不同表面免疫球蛋白同种型的B淋巴细胞的功能差异。
Cell surface immunoglobulin. XVIII. Functional differences of B lymphocytes bearing different surface immunoglobulin isotypes.
作者信息
Vitetta E S, Forman J, Kettman J R
出版信息
J Exp Med. 1976 May 1;143(5):1055-65. doi: 10.1084/jem.143.5.1055.
Abstract
Three populations of murine splenic B lymphocytes have been characterized previously (6, 7, 9) as those bearing only IgM, those bearing only IgD, and a population bearing both isotopes. These studies were designed to test the response of the IgM+ cells (IgM-only or IgM plus IgD) vs. the IgD-only cells to the B-cell mitogen, lipopolysaccharide. Results that after 1-4 days of culture, in the presence of mitogen, the IgM+ cells enlarge and elaborate an IgM polyclonal response. The IgD-only cells, in contrast, do not exhibit an IgM polyclonal response, but instead undergo blastogenesis and proliferation.
摘要
先前已鉴定出三组小鼠脾脏B淋巴细胞（6、7、9），即仅携带IgM的细胞、仅携带IgD的细胞以及同时携带两种同型抗体的细胞群。这些研究旨在测试IgM+细胞（仅IgM或IgM加IgD）与仅IgD细胞对B细胞有丝分裂原脂多糖的反应。结果表明，在有丝分裂原存在的情况下培养1-4天后，IgM+细胞会增大并产生IgM多克隆反应。相比之下，仅IgD细胞不会表现出IgM多克隆反应，而是经历原始细胞形成和增殖。
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