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1
The relationship between surface immunoglobulin isotype and immune function of murine B lymphocytes. III. Expression of a single predominant isotype on primed and unprimed B cells.小鼠B淋巴细胞表面免疫球蛋白同种型与免疫功能的关系。III. 致敏和未致敏B细胞上单一主要同种型的表达。
J Exp Med. 1978 May 1;147(5):1374-94. doi: 10.1084/jem.147.5.1374.
2
The relationship between surface immunoglobulin isotype and immune function of murine B lymphocytes. I. Surface immunoglobulin isotypes on primed B cells in the spleen.小鼠B淋巴细胞表面免疫球蛋白同种型与免疫功能的关系。I. 脾脏中致敏B细胞上的表面免疫球蛋白同种型。
J Exp Med. 1977 May 1;145(5):1188-205. doi: 10.1084/jem.145.5.1188.
3
The relationship between surface immunoglobulin isotype and immune function of murine B lymphocytes II. Surface immunoglobulin isotopes on unprimed B cells in the spleen.小鼠B淋巴细胞表面免疫球蛋白同种型与免疫功能的关系II. 脾脏中未致敏B细胞上的表面免疫球蛋白同种型
J Exp Med. 1977 May 1;145(5):1206-15. doi: 10.1084/jem.145.5.1206.
4
Most B cells that have switched surface immunoglobulin isotypes generate clones of cells that do not secrete IgM.大多数已经转换表面免疫球蛋白同种型的B细胞会产生不分泌IgM的细胞克隆。
J Immunol. 1981 Sep;127(3):1030-4.
5
Cell surface immunoglobulin. XX. Antibody responsiveness of subpopulations of B lymphocytes bearing different isotypes.细胞表面免疫球蛋白。XX. 携带不同同种型的B淋巴细胞亚群的抗体反应性。
J Exp Med. 1977 Jun 1;145(6):1421-35. doi: 10.1084/jem.145.6.1421.
6
Lymphoid cell dependence of eosinophil response to antigen. VI. The effect of selective removal of T or B lymphocytes on the capacity of primed spleen cells to adoptively transferred immunity to tetanus toxoid.嗜酸性粒细胞对抗原反应的淋巴细胞依赖性。VI. 选择性去除T或B淋巴细胞对致敏脾细胞过继转移破伤风类毒素免疫能力的影响。
Immunology. 1975 Feb;28(2):243-51.
7
The relationship between surface immunoglobulin isotype and immune function of murine B lymphocytes. V. IgD-bearing cells in immunological tolerance.小鼠B淋巴细胞表面免疫球蛋白同种型与免疫功能的关系。V. 免疫耐受中的IgD阳性细胞
Eur J Immunol. 1982 Oct;12(10):838-44. doi: 10.1002/eji.1830121008.
8
Expression of IgD by murine lymphocytes. Loss of surface IgD indicates maturation of memory B cells.小鼠淋巴细胞IgD的表达。表面IgD的缺失表明记忆B细胞的成熟。
J Exp Med. 1978 Apr 1;147(4):984-96. doi: 10.1084/jem.147.4.984.
9
The relationship between surface immunoglobulin isotype and the immune function of murine B lymphocytes. V. High affinity secondary antibody responses are transferred by both IgD-positive and IgD-negative memory B cells.小鼠B淋巴细胞表面免疫球蛋白同种型与免疫功能的关系。V. IgD阳性和IgD阴性记忆B细胞均可传递高亲和力二次抗体应答。
J Immunol. 1981 Sep;127(3):867-72.
10
Physiology of IgD. III. Effect of treatment with anti-IgD from birth on the magnitude and isotype distribution of the immune response in the spleen.免疫球蛋白D的生理学。III. 从出生起用抗免疫球蛋白D治疗对脾脏免疫反应的强度和同种型分布的影响。
Eur J Immunol. 1984 Jan;14(1):81-6. doi: 10.1002/eji.1830140115.

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1
T cell-dependent IgM memory B cells generated during bacterial infection are required for IgG responses to antigen challenge.在细菌感染过程中产生的依赖 T 细胞的 IgM 记忆 B 细胞对于针对抗原挑战的 IgG 反应是必需的。
J Immunol. 2013 Aug 1;191(3):1240-9. doi: 10.4049/jimmunol.1300062. Epub 2013 Jun 26.
2
Interleukin-5 induces maturation but not class switching of surface IgA-positive B cells into IgA-secreting cells.白细胞介素-5可诱导表面IgA阳性B细胞成熟为IgA分泌细胞，但不会诱导其类别转换。
Immunology. 1989 Jan;66(1):32-8.
3
Human B lymphocyte subsets. I. IgG-bearing B cell response to pokeweed mitogen.人类B淋巴细胞亚群。I. 携带IgG的B细胞对商陆有丝分裂原的反应。
J Exp Med. 1981 Feb 1;153(2):339-51. doi: 10.1084/jem.153.2.339.
4
Simultaneous expression of immunoglobulin mu and delta heavy chains by a cloned B-cell lymphoma: a single copy of the VH gene is shared by two adjacent CH genes.一个克隆的B细胞淋巴瘤同时表达免疫球蛋白μ链和δ重链：两个相邻的CH基因共享一个VH基因单拷贝。
Proc Natl Acad Sci U S A. 1982 May;79(9):2996-3000. doi: 10.1073/pnas.79.9.2996.
5
Independent regulation of IgM, IgD, and Ia antigen expression in cultured immature B lymphocytes.培养的未成熟B淋巴细胞中IgM、IgD和Ia抗原表达的独立调节
J Exp Med. 1986 Apr 1;163(4):938-51. doi: 10.1084/jem.163.4.938.
6
Double isotype production by a neoplastic B cell line. II. Allelically excluded production of mu and gamma 1 heavy chains without CH gene rearrangement.肿瘤性B细胞系的双同种型产生。II. 无CH基因重排的μ链和γ1重链的等位基因排斥产生
J Exp Med. 1986 Aug 1;164(2):562-79. doi: 10.1084/jem.164.2.562.
7
Double isotype production by a neoplastic B cell line. I. Cellular and biochemical characterization of a variant of BCL1 that expresses and secretes both IgM and IgG1.肿瘤性B细胞系产生的双同种型。I. 表达并分泌IgM和IgG1的BCL1变体的细胞和生化特征
J Exp Med. 1986 Aug 1;164(2):548-61. doi: 10.1084/jem.164.2.548.
8
Differences in glycoprotein complexes associated with IgM and IgD on normal murine B cells potentially enable transduction of different signals.正常鼠类B细胞上与IgM和IgD相关的糖蛋白复合物差异可能使不同信号得以转导。
EMBO J. 1990 Jul;9(7):2117-24. doi: 10.1002/j.1460-2075.1990.tb07380.x.
9
Bacterial lipopolysaccharide activates suppressor B lymphocytes.细菌脂多糖激活抑制性B淋巴细胞。
Proc Natl Acad Sci U S A. 1979 Sep;76(9):4608-12. doi: 10.1073/pnas.76.9.4608.
10
The response to lipopolysaccharide of mouse spleen lymphocytes fractionated on the basis of surface immunoglobulin and complement receptor using fluorescence-activated cell sorting and rosetting techniques.使用荧光激活细胞分选和花环形成技术，对基于表面免疫球蛋白和补体受体进行分离的小鼠脾脏淋巴细胞的脂多糖反应。
Immunology. 1979 Apr;36(4):865-73.

本文引用的文献

1
Fluorescence activated cell sorting.荧光激活细胞分选
Rev Sci Instrum. 1972 Mar;43(3):404-9. doi: 10.1063/1.1685647.
2
Restriction of gene expression in B lymphocytes and their progeny. I. Commitment to immunoglobulin allotype.B淋巴细胞及其后代中基因表达的限制。I. 对免疫球蛋白同种异型的定向。
J Exp Med. 1974 Mar 1;139(3):581-99. doi: 10.1084/jem.139.3.581.
3
A rapid method for the isolation of functional thymus-derived murine lymphocytes.一种分离功能性胸腺来源的小鼠淋巴细胞的快速方法。
Eur J Immunol. 1973 Oct;3(10):645-9. doi: 10.1002/eji.1830031011.
4
Maturation of B lymphocytes in the rat. I. Migration pattern, tissue distribution, and turnover rate of unprimed and primed B lymphocytes involved in the adoptive antidinitrophenyl response.大鼠B淋巴细胞的成熟。I. 参与过继性抗二硝基苯反应的未致敏和致敏B淋巴细胞的迁移模式、组织分布及更新率。
J Exp Med. 1973 Dec 1;138(6):1331-44. doi: 10.1084/jem.138.6.1331.
5
Immune responses in vitro. V. Suppression of M, G, and A plaque-forming cell responses in cultures of primed mouse spleen cells by class-specific antibody to mouse immunoglobulins.体外免疫反应。V. 用小鼠免疫球蛋白类特异性抗体对致敏小鼠脾细胞培养物中M、G和A斑块形成细胞反应的抑制作用。
J Exp Med. 1972 Mar 1;135(3):698-710. doi: 10.1084/jem.135.3.698.
6
Immune responses in vitro. IV. Suppression of primary M, G, and A plaque-forming cell responses in mouse spleen cell cultures by class-specific antibody to mouse immunoglobulins.体外免疫反应。IV. 用小鼠免疫球蛋白的类特异性抗体抑制小鼠脾细胞培养物中初级M、G和A斑块形成细胞反应。
J Exp Med. 1972 Mar 1;135(3):675-97. doi: 10.1084/jem.135.3.675.
7
Demonstration that IgG memory is carried by IgG-bearing cells.证实IgG记忆由携带IgG的细胞携带。
Eur J Immunol. 1976 Jul;6(7):467-72. doi: 10.1002/eji.1830060704.
8
Maturation of b lymphocytes in rates. III. Two subpopulations of memory B cells in the thoracic duct lymph differ by size, turnover rate, and surface immunoglobulin.大鼠B淋巴细胞的成熟。III. 胸导管淋巴液中记忆B细胞的两个亚群在大小、更新率和表面免疫球蛋白方面存在差异。
J Immunol. 1976 Oct;117(4):1288-94.
9
The class of surface immunoglobulin on cells carrying IgG memory in rat thoracic duct lymph: the size of the subpopulation mediating IgG memory.大鼠胸导管淋巴液中携带IgG记忆的细胞上的表面免疫球蛋白类别：介导IgG记忆的亚群大小
J Exp Med. 1976 May 1;143(5):1122-30. doi: 10.1084/jem.143.5.1122.
10
Cell surface immunoglobulin. XVIII. Functional differences of B lymphocytes bearing different surface immunoglobulin isotypes.细胞表面免疫球蛋白。十八。携带不同表面免疫球蛋白同种型的B淋巴细胞的功能差异。
J Exp Med. 1976 May 1;143(5):1055-65. doi: 10.1084/jem.143.5.1055.

小鼠B淋巴细胞表面免疫球蛋白同种型与免疫功能的关系。III. 致敏和未致敏B细胞上单一主要同种型的表达。

The relationship between surface immunoglobulin isotype and immune function of murine B lymphocytes. III. Expression of a single predominant isotype on primed and unprimed B cells.

作者信息

Zan-Bar I, Vitetta E S, Assisi F, Strober S

出版信息

J Exp Med. 1978 May 1;147(5):1374-94. doi: 10.1084/jem.147.5.1374.

DOI:10.1084/jem.147.5.1374
PMID:306414
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2184263/
Abstract

We determined whether primed and unprimed B cells in the spleen of (BALB/c x C57BL/Ka)F(1) mice contain subpopulations that express a predominant surface Ig isotype. Spleen cells were stained for surface isotypes and sorted on the fluorescence-activated cell sorter (FACS) in order to obtain B cells bearing predominantly IgM (mup cells), IgD (deltap cells), or IgG (gammap cells). Each population was assayed for its capacity to restore the adoptive primary and secondary anti-bovine serum albumin (BSA) antibody response in irradiated syngeneic recipients. In addition, the adoptive response restored by isotype-predominant cells was compared to that restored by isotype- positive cells (B cells bearing a given surface isotype alone or in combination with others). The experimental results show that mup cells restore the adoptive primary and secondary IgM and IgG responses to BSA, and gammaP cells restore only the primary and secondary IgG response. Deltap Cells restored the adoptive secondary IgG response, but failed to restore the adoptive primary response at the cell doses tested. GammaP Cells but not deltap cells suppressed the IgM response of the mu(+) and delta(+) cells. The contribution of isotype-predominant cells to both the adoptive primary and secondary anti-BSA response was smaller than that of B cells bearing a combination of surface isotypes. Differences in the Ig isotype pattern expressed on the surface of primed and unprimed B cells are discussed.

摘要

我们确定了（BALB/c×C57BL/Ka）F1小鼠脾脏中已致敏和未致敏的B细胞是否包含表达主要表面免疫球蛋白同种型的亚群。对脾细胞进行表面同种型染色，并在荧光激活细胞分选仪（FACS）上进行分选，以获得主要携带IgM的B细胞（mup细胞）、IgD的B细胞（deltap细胞）或IgG的B细胞（gammap细胞）。检测每个亚群在受辐照的同基因受体中恢复过继性初次和二次抗牛血清白蛋白（BSA）抗体反应的能力。此外，将同种型主要细胞恢复的过继性反应与同种型阳性细胞（仅携带给定表面同种型或与其他同种型组合的B细胞）恢复的过继性反应进行比较。实验结果表明，mup细胞恢复了对BSA的过继性初次和二次IgM及IgG反应，而gammap细胞仅恢复了初次和二次IgG反应。Deltap细胞恢复了过继性二次IgG反应，但在所测试的细胞剂量下未能恢复过继性初次反应。Gammap细胞而非deltap细胞抑制了mu(+)和delta(+)细胞的IgM反应。同种型主要细胞对过继性初次和二次抗BSA反应的贡献小于携带表面同种型组合的B细胞。文中讨论了已致敏和未致敏B细胞表面表达的免疫球蛋白同种型模式的差异。