Hume W J, Potten C S
J Oral Pathol. 1979 Feb;8(1):3-22. doi: 10.1111/j.1600-0714.1979.tb01618.x.
There is growing evidence that the basal layer of stratified squamous epithelia consists of cells of differing proliferative capacities and behaviour. These can be classified as stem cells, transient amplifying cells and post-mitotic maturing cells, the most important of which appear to be the stem cells which may be present throughout life and are responsible for all cell production under steady-state conditions. Recent stem cell concepts are reviewed for epidermis, intestinal crypt and oral mucosa and are compared with tissues such as bone marrow and testes which have for some time been thought to operate in a similar manner. These concepts are applied to several pathological conditions of oral epithelia in an attempt to explain some of the changes observed.
越来越多的证据表明，复层鳞状上皮的基底层由具有不同增殖能力和行为的细胞组成。这些细胞可分为干细胞、短暂增殖细胞和有丝分裂后成熟细胞，其中最重要的似乎是干细胞，它们可能终生存在，并在稳态条件下负责所有细胞的产生。本文综述了表皮、肠隐窝和口腔黏膜的最新干细胞概念，并与骨髓和睾丸等组织进行了比较，这些组织长期以来被认为以类似的方式运作。这些概念被应用于口腔上皮的几种病理状况，试图解释观察到的一些变化。
