实验性口腔黏膜致癌过程中的基底细胞核大小
Basal cell nuclear size in experimental oral mucosal carcinogenesis.
作者信息
Rich A M, Nataatmadja M I, Reade P C
机构信息
Section of Oral Medicine and Oral Surgery, School of Dental Science, University of Melbourne, Victoria, Australia.
出版信息
Br J Cancer. 1991 Jul;64(1):96-8. doi: 10.1038/bjc.1991.248.
It has been suggested that the size of the nuclei of epithelial basal cells can be used in predicting the likelihood of malignant transformation of epithelium. This proposition was assessed in rat palatal epithelium after the carcinogen 4-nitroquinoline-1-oxide had been applied to the epithelium for varying periods of time. No consistent alterations in basal cell nuclear size, including area, perimeter, diameter and regularity of form were found with routine light microscopy as the epithelium passed through various stages of dysplasia to carcinoma. This finding casts doubt on the value of using a variation of basal cell nuclear size as a predictor of malignant transformation.
有人提出，上皮基底细胞核的大小可用于预测上皮恶性转化的可能性。在用致癌物4-硝基喹啉-1-氧化物对大鼠腭上皮施加不同时间后，对这一观点进行了评估。随着上皮细胞经历发育异常到癌变的各个阶段，常规光学显微镜检查未发现基底细胞核大小（包括面积、周长、直径和形态规则性）有一致的变化。这一发现使人怀疑将基底细胞核大小的变化作为恶性转化预测指标的价值。
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