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膜结构在B淋巴细胞活化中的作用。抗免疫球蛋白、聚合IgG和免疫复合物结合的影响。

Role of membrane structures in B-lymphocyte activation. The effect of binding anti-immunoglobulin, aggregated IgG and immune complexes.

作者信息

Ramasamy R

出版信息

Immunology. 1976 Apr;30(4):559-64.

PMID:1083830
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1445019/
Abstract

It is shown that the binding of bivalent anti-immunoglobulin preparations to the surface immunoglobulin of murine B lymphocytes as well as the binding of aggregates of IgG or immune complexes does not lead to detectable increase in cell division in microcultures. Treating lymphocytes with immune complexes and aggregated IgG does not abolish the subsequent mitogenic response induced by LPS. The background mitosis observed in culture is inhibited with anti-immunoglobulin antibodies.

摘要

结果表明，二价抗免疫球蛋白制剂与鼠B淋巴细胞表面免疫球蛋白的结合以及IgG聚集体或免疫复合物的结合，在微量培养中不会导致可检测到的细胞分裂增加。用免疫复合物和聚集的IgG处理淋巴细胞不会消除随后由LPS诱导的促有丝分裂反应。培养中观察到的背景有丝分裂被抗免疫球蛋白抗体抑制。

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Role of membrane structures in B-lymphocyte activation. The effect of binding anti-immunoglobulin, aggregated IgG and immune complexes.膜结构在B淋巴细胞活化中的作用。抗免疫球蛋白、聚合IgG和免疫复合物结合的影响。
Immunology. 1976 Apr;30(4):559-64.
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引用本文的文献

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Regulation of the immune response. I. The potentiation of in vivo and in vitro immune responses by Fc fragments.免疫反应的调节。I. Fc片段对体内和体外免疫反应的增强作用。
J Exp Med. 1980 Jul 1;152(1):113-23. doi: 10.1084/jem.152.1.113.
2
Human B cell activation. Evidence for diverse signals provided by various monoclonal anti-IgM antibodies.人类B细胞活化。各种单克隆抗IgM抗体提供不同信号的证据。
J Exp Med. 1985 Oct 1;162(4):1236-55. doi: 10.1084/jem.162.4.1236.
3
B-lymphocytes activation by the Fc region of IgG.B淋巴细胞被IgG的Fc区域激活。
J Exp Med. 1977 Jul 1;146(1):241-56. doi: 10.1084/jem.146.1.241.

本文引用的文献

1
Studies on rabbit lymphocytes in vitro. 3. Proteins, RNA, and DNA synthesis by lymphocyte cultures after stimulation with phytohaemagglutinin, with staphylococcal filtrate, with antiallotype serum, and with heterologous antiserum to rabbit whole serum.兔淋巴细胞的体外研究。3. 用植物血凝素、葡萄球菌滤液、抗同种异型血清以及兔全血清的异种抗血清刺激后淋巴细胞培养物中的蛋白质、RNA和DNA合成。
J Exp Med. 1965 Oct 1;122(4):823-39. doi: 10.1084/jem.122.4.823.
2
The effect of capping by anti-immunoglobulin antibody on the expression of cell surface immunoglobulin and on lymphocyte activation.抗免疫球蛋白抗体封端对细胞表面免疫球蛋白表达及淋巴细胞活化的影响。
Scand J Immunol. 1973;2(2):143-9. doi: 10.1111/j.1365-3083.1973.tb02025.x.
3
Possible role for the Fc receptor on B lymphocytes.B淋巴细胞上Fc受体的潜在作用。
Nature. 1974 Jun 7;249(457):573-4. doi: 10.1038/249573a0.
4
Synthesis, transport, dynamics and fate of cell surface Ig and alloantigens in murine lymphocytes.小鼠淋巴细胞中细胞表面免疫球蛋白和同种异体抗原的合成、运输、动态变化及命运
Transplant Rev. 1973;14:50-75. doi: 10.1111/j.1600-065x.1973.tb00102.x.
5
Inhibition of mitogenic stimulation of mouse lymphocytes by anti-mouse immunoglobulin antibodies. I. Mode of action.抗小鼠免疫球蛋白抗体对小鼠淋巴细胞有丝分裂刺激的抑制作用。I. 作用方式。
Eur J Immunol. 1974 Nov;4(11):715-22. doi: 10.1002/eji.1830041103.
6
Induction of DNA synthesis in normal human lymphocyte cultures by antigen-antibody complexes.抗原-抗体复合物诱导正常人淋巴细胞培养物中的DNA合成。
Clin Exp Immunol. 1969 Jan;4(1):65-82.
7
Evidence for identity or close association of the Fc receptor of B lymphocytes and alloantigens determined by the Ir region of the H-2 complex.关于B淋巴细胞的Fc受体与由H-2复合体的Ir区域所决定的同种异体抗原的同一性或紧密关联的证据。
J Exp Med. 1974 Sep 1;140(3):779-96. doi: 10.1084/jem.140.3.779.
8
Biochemical and biological characteristics of lymphocyte surface immunoglobulin.淋巴细胞表面免疫球蛋白的生化与生物学特性
Transplant Rev. 1973;14:3-49. doi: 10.1111/j.1600-065x.1973.tb00101.x.
9
Development of restrictions in the expression of immunoglobulin specificities by lymphoid cells.淋巴细胞免疫球蛋白特异性表达限制的发展。
Transplant Rev. 1970;5:19-44. doi: 10.1111/j.1600-065x.1970.tb00355.x.
10
Functional analysis of murine and human B lymphocyte subsets.小鼠和人类B淋巴细胞亚群的功能分析。
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