免疫反应的调节。I. Fc片段对体内和体外免疫反应的增强作用。
Regulation of the immune response. I. The potentiation of in vivo and in vitro immune responses by Fc fragments.
作者信息
Morgan E L, Walker S M, Thoman M L, Weigle W O
出版信息
J Exp Med. 1980 Jul 1;152(1):113-23. doi: 10.1084/jem.152.1.113.
Abstract
Fc fragments derived from human and murine Ig were found to be potent adjuvants when administered with antigen. Both the in vivo and in vitro anti- sheep erythrocytes (SRBC) responses were significantly enhanced by Fc fragments. The adjuvant effect was shown to be extremely dependent upon the dose of antigen used, with the greatest enhancement occurring when suboptimal doses of antigen are employed. The anti-genicity of the Fc molecule was not related to its adjuvanticity because homologous Fc was as potent an adjuvant as heterologous Fc. Moreover, human Fc fragments enhanced anti-SRBC responses in mice which were tolerant to human gamma globulin.
摘要
当与抗原一起给药时，发现源自人源和鼠源Ig的Fc片段是有效的佐剂。Fc片段显著增强了体内和体外抗绵羊红细胞（SRBC）反应。佐剂效应显示出极大地依赖于所用抗原的剂量，当使用次优剂量的抗原时增强作用最大。Fc分子的抗原性与其佐剂性无关，因为同源Fc与异源Fc一样是有效的佐剂。此外，人Fc片段增强了对人γ球蛋白耐受的小鼠的抗SRBC反应。
相似文献
1
Regulation of the immune response. I. The potentiation of in vivo and in vitro immune responses by Fc fragments.免疫反应的调节。I. Fc片段对体内和体外免疫反应的增强作用。
J Exp Med. 1980 Jul 1;152(1):113-23. doi: 10.1084/jem.152.1.113.
2
3
Potentiation of specific human in vitro immune responses by the Fc portion of human immunoglobulin.人免疫球蛋白Fc部分对特定人体外免疫反应的增强作用。
Clin Exp Immunol. 1983 Aug;53(2):505-11.
4
5
Fc-dependent IgG-mediated suppression of the antibody response: fact or artefact?Fc 依赖性 IgG 介导的抗体应答抑制：事实还是假象？
Scand J Immunol. 1990 May;31(5):601-7. doi: 10.1111/j.1365-3083.1990.tb02811.x.
6
Synthetic Fc peptide-mediated regulation of the immune response. I. Characterization of the immunomodulating properties of a synthetic 23-amino acid peptide derived from the sequence of the CH3 domain of human IgG1.合成Fc肽介导的免疫反应调节。I. 源自人IgG1 CH3结构域序列的23个氨基酸合成肽免疫调节特性的表征。
J Exp Med. 1983 Mar 1;157(3):947-56. doi: 10.1084/jem.157.3.947.
7
8
Activation of T lymphocytes by the Fc portion of immunoglobulin.免疫球蛋白Fc部分对T淋巴细胞的激活。
J Supramol Struct. 1980;13(4):479-88. doi: 10.1002/jss.400130407.
9
The effect of adjuvant induced suppressor cells on in vitro and in vivo lymphocyte responses.佐剂诱导的抑制细胞对体外和体内淋巴细胞反应的影响。
Adv Exp Med Biol. 1979;114:351-5. doi: 10.1007/978-1-4615-9101-6_56.
10
In vivo immune response to a T-cell-dependent antigen by cultures of disassociated murine Peyer's patch.用分离的小鼠派尔集合淋巴结培养物对T细胞依赖性抗原的体内免疫反应。
Proc Natl Acad Sci U S A. 1982 Jan;79(2):596-600. doi: 10.1073/pnas.79.2.596.
引用本文的文献
1
Prevention and treatment of influenza with hyperimmune bovine colostrum antibody.用牛初乳抗体进行流感的预防和治疗。
PLoS One. 2010 Oct 26;5(10):e13622. doi: 10.1371/journal.pone.0013622.
2
Reversal of immune complex inhibition of antibody-dependent cell-mediated cytotoxicity by normal human serum.正常人血清对免疫复合物介导的抗体依赖性细胞介导的细胞毒性的逆转作用。
Clin Exp Immunol. 1982 Jun;48(3):685-92.
3
Studies of the immunological activities of the outer membrane protein from Escherichia coli.大肠杆菌外膜蛋白免疫活性的研究
Immunology. 1982 Jun;46(2):271-80.
4
Anaphylatoxin-mediated regulation of the immune response. I. C3a-mediated suppression of human and murine humoral immune responses.过敏毒素介导的免疫反应调节。I. C3a介导的对人和小鼠体液免疫反应的抑制。
J Exp Med. 1982 May 1;155(5):1412-26. doi: 10.1084/jem.155.5.1412.
5
Polyclonal activation of human B lymphocytes by Fc fragments. I. Characterization of the cellular requirements for Fc fragment-mediated polyclonal antibody secretion by human peripheral blood B lymphocytes.Fc片段对人B淋巴细胞的多克隆激活。I.人外周血B淋巴细胞通过Fc片段介导多克隆抗体分泌的细胞需求特征
J Exp Med. 1981 Sep 1;154(3):778-90. doi: 10.1084/jem.154.3.778.
6
Potentiation of specific human in vitro immune responses by the Fc portion of human immunoglobulin.人免疫球蛋白Fc部分对特定人体外免疫反应的增强作用。
Clin Exp Immunol. 1983 Aug;53(2):505-11.
7
Enhancement of T lymphocyte functions by Fc fragments of immunoglobulins. I. Augmentation of allogeneic mixed lymphocyte culture reactions requires I-A- or I-B-subregion differences between effector and stimulator cell populations.免疫球蛋白Fc片段对T淋巴细胞功能的增强作用。I. 同种异体混合淋巴细胞培养反应的增强需要效应细胞和刺激细胞群体之间存在I-A或I-B亚区差异。
J Exp Med. 1981 May 1;153(5):1161-72. doi: 10.1084/jem.153.5.1161.
8
Synthetic Fc peptide-mediated regulation of the immune response. I. Characterization of the immunomodulating properties of a synthetic 23-amino acid peptide derived from the sequence of the CH3 domain of human IgG1.合成Fc肽介导的免疫反应调节。I. 源自人IgG1 CH3结构域序列的23个氨基酸合成肽免疫调节特性的表征。
J Exp Med. 1983 Mar 1;157(3):947-56. doi: 10.1084/jem.157.3.947.
9
Fc receptor--more answers, more questions.Fc受体——更多答案，更多问题。
Folia Microbiol (Praha). 1984;29(6):476-516. doi: 10.1007/BF02873160.
10
The role of complement in the induction and regulation of immune responses.补体在免疫反应的诱导和调节中的作用。
Immunology. 1984 Feb;51(2):207-24.
本文引用的文献
1
Regulation of the immune response. I. Differential effect of passively administered antibody on the thymus-derived and bone marrow-derived lymphocytes.免疫反应的调节。I. 被动给予抗体对胸腺来源淋巴细胞和骨髓来源淋巴细胞的不同作用。
J Exp Med. 1971 Sep 1;134(3 Pt 1):577-87. doi: 10.1084/jem.134.3.577.
2
The hydrolysis of rabbit y-globulin and antibodies with crystalline papain.用结晶木瓜蛋白酶对兔γ球蛋白和抗体进行水解。
Biochem J. 1959 Sep;73(1):119-26. doi: 10.1042/bj0730119.
3
4
Plaque formation in agar by single antibody-producing cells.单个产生抗体的细胞在琼脂中形成菌斑。
Science. 1963 Apr 26;140(3565):405.
5
6
Regulation of Fc fragment-induced murine spleen cell proliferation.Fc片段诱导的小鼠脾细胞增殖的调控
J Exp Med. 1980 Jan 1;151(1):1-11. doi: 10.1084/jem.151.1.1.
7
Immunization of dissociated spleen cell cultures from normal mice.对来自正常小鼠的脾细胞解离培养物进行免疫接种。
J Exp Med. 1967 Sep 1;126(3):423-42. doi: 10.1084/jem.126.3.423.
8
9
The immunosuppressive effect of passively administered antibody IgG fragments.被动给予的抗体IgG片段的免疫抑制作用。
J Immunol. 1969 Apr;102(4):1008-15.
10
Specificity of the immunosuppression caused by passive administration of antibody.被动给予抗体所引起的免疫抑制的特异性。
J Immunol. 1969 Aug;103(2):268-75.
Zotero 插件