Vasterling J J, Brailey K, Sutker P B
Mental Health Service Line (COS6), Veterans Affairs Medical Center, New Orleans, Louisiana 70112, USA.
J Trauma Stress. 2000 Apr;13(2):241-53. doi: 10.1023/A:1007754611030.
Recent neuropsychological conceptualizations of posttraumatic stress disorder (PTSD) implicate dysfunction of the fronto-limbic system, a brain system thought to be involved in the mediation of emotion. However, few studies have examined fronto-limbic subregions, such as the orbitofrontal cortex, in PTSD. As a measure of orbitofrontal integrity, olfactory identification was assessed in 26 Vietnam War veterans with PTSD, 25 Vietnam War veterans without mental disorders, and 17 Vietnam-era, non-war-zone veterans without mental disorders. Relative to veterans without PTSD, those diagnosed with PTSD were less proficient in odor identification and verbal learning but not on other cognitive tests sensitive to dorsolateral prefrontal and mesial temporal functioning. Results bolster prior research indicating fronto-limbic dysfunction in PTSD, and suggest involvement of the orbitofrontal region.
近期对创伤后应激障碍（PTSD）的神经心理学概念认为，前额叶-边缘系统功能失调，该脑系统被认为参与情绪调节。然而，很少有研究在PTSD中考察前额叶-边缘系统的亚区域，如眶额叶皮质。作为眶额叶完整性的一项指标，对26名患有PTSD的越战老兵、25名无精神障碍的越战老兵以及17名越战时期非战区无精神障碍的老兵进行了嗅觉识别评估。与无PTSD的老兵相比，被诊断为PTSD的老兵在气味识别和言语学习方面表现较差，但在对背外侧前额叶和内侧颞叶功能敏感的其他认知测试中则不然。研究结果支持了先前表明PTSD中前额叶-边缘系统功能失调的研究，并提示眶额叶区域也参与其中。
