Zumegen C, Thomas J P, Michel O
Klinik und Poliklinik für Hals-Nasen-Ohrenheilkunde, Universität zu Köln.
Laryngorhinootologie. 2000 Apr;79(4):221-5. doi: 10.1055/s-2000-8991.
The inverted papilloma of the nasal cavity and the paranasal sinuses is a benign but locally aggressive neoplasm with a high recurrence rate and an unknown risk of malign transformation. This unsteadiness of biological behaviour requires a permanent control of the outcome of the available surgical treatments to ensure the utmost reliability for the patients.
In our investigation we analysed the surgical results in 54 patients with inverted papilloma of the last 30 years with an average followup of 55 months. 25 of them were endoscopically treated. The other group of 29 patients was treated by traditional surgical techniques using an extra-nasal approach.
Using the endonasal-endoscopic technique we observed a recurrence rate of 48% whereas the other group treated by an extra-nasal approach reached a recurrence rate of only 24% and did not show any multiple recurrences. A malign transformation was found in two patients (< 5%) within the first 8 months after the first resection.
In consequence patients with inverted papilloma have to be informed of the different surgical techniques and their recurrence rates. Especially an endonasal-endoscopic treatment of the maxillary sinus has to be carefully considered.
鼻腔及鼻窦内翻性乳头状瘤是一种良性但具有局部侵袭性的肿瘤，复发率高，恶变风险未知。这种生物学行为的不稳定性需要对现有手术治疗的结果进行长期监测，以确保为患者提供最大程度的可靠性。
在我们的研究中，我们分析了过去30年中54例内翻性乳头状瘤患者的手术结果，平均随访55个月。其中25例接受了内镜治疗。另一组29例患者采用传统鼻外手术技术治疗。
采用鼻内镜技术，我们观察到复发率为48%，而另一组采用鼻外手术治疗的复发率仅为24%，且未出现任何多次复发情况。在首次切除后的前8个月内，两名患者（<5%）发生了恶变。
因此，必须告知内翻性乳头状瘤患者不同的手术技术及其复发率。特别是上颌窦的鼻内镜治疗必须谨慎考虑。
